Lolitrem B and Indole Diterpene Alkaloids Produced by Endophytic Fungi of the Genus Epichloë and Their Toxic Effects in Livestock

Toxins
Guerre Philippe

Abstract

Different group of alkaloids are produced during the symbiotic development of fungal endophytes of the genus Epichloë in grass. The structure and toxicity of the compounds vary considerably in mammalian herbivores and in crop pests. Alkaloids of the indole-diterpene group, of which lolitrem B is the most toxic, were first characterized in endophyte-infected perennial ryegrass, and are responsible for "ryegrass staggers." Ergot alkaloids, of which ergovaline is the most abundant ergopeptide alkaloid produced, are also found in ryegrass, but generally at a lower rate than lolitrem B. Other alkaloids such as lolines and peramine are toxic for crop pests but have weak toxicological properties in mammals. The purpose of this review is to present indole-diterpene alkaloids produced in endophyte infected ryegrass from the first characterization of ryegrass staggers to the determination of the toxicokinetics of lolitrem B and of their mechanism of action in mammals, focusing on the different factors that could explain the worldwide distribution of the disease. Other indole diterpene alkaloids than lolitrem B that can be found in Epichloë infected ryegrass, and their tremorgenic properties, are presented in the last section of this review.

References

Sep 1, 1977·Journal of Agricultural and Food Chemistry·R J ColeD M Bedell
Jan 1, 1991·Journal of Natural Products·M I SelalaP Schepens
Nov 9, 1987·Life Sciences·D B GantA T Eldefrawi
Feb 1, 1964·New Zealand Veterinary Journal·R H Thornton
Jan 1, 1980·Journal of Neurochemistry·P J NorrisR H Penny
Oct 1, 1981·New Zealand Veterinary Journal·L R Fletcher, I C Harvey
Feb 17, 1998·Applied and Environmental Microbiology·C O MilesG C Latch
Aug 2, 2001·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·J T Hovermale, A M Craig
Oct 20, 2001·The Journal of Veterinary Medical Science·S MiyazakiN Yamanaka
Jan 5, 2002·Crop Science·H. S. EastonO. J.-P. Ball
Jun 24, 2003·Journal of Animal Science·M S GadberryE L Piper
Aug 13, 2004·Journal of Veterinary Diagnostic Investigation : Official Publication of the American Association of Veterinary Laboratory Diagnosticians, Inc·Shigeru MiyazakiYuriko Ishiguro-Takeda
Nov 6, 2004·Applied and Environmental Microbiology·Shuguang ZhangBarry Scott
Nov 1, 1982·New Zealand Veterinary Journal·R T GallagherI C Harvey
Jun 13, 2006·Fungal Genetics and Biology : FG & B·Carolyn A YoungBarry Scott
Mar 10, 2007·Phytochemistry·Christopher L SchardlUma P Mallik
Sep 20, 2008·The Journal of Pharmacology and Experimental Therapeutics·Wendy L ImlachJulie E Dalziel
Feb 3, 2009·Applied and Environmental Microbiology·Carolyn A YoungBarry Scott
Feb 13, 2009·European Journal of Pharmacology·Wendy L ImlachJulie E Dalziel
Jul 29, 2010·Trends in Neurosciences·Urvi S Lee, Jianmin Cui
Dec 20, 2011·New Zealand Veterinary Journal·S C FinchJ V Babu
Sep 19, 2012·New Zealand Veterinary Journal·S C FinchC D Waugh
Jun 1, 2013·Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment·Nobuaki ShimadaShigeru Miyazaki
Aug 31, 2013·Journal of Animal Science·J E DalzielS C Finch
Sep 3, 2014·Natural Product Reports·Wei XuYi Tang
Apr 24, 2015·BMC Evolutionary Biology·Inoka K HettiarachchigeJohn W Forster
Nov 10, 2015·Journal of Agricultural and Food Chemistry·Joseph Raymond MooreLeslie Ann Weston

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Citations

Sep 23, 2016·Frontiers in Microbiology·Hui SongQingping Zhang
Jun 13, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Ingrid P de SousaNiege A Jacometti Cardoso Furtado
Jun 21, 2020·World Journal of Microbiology & Biotechnology·R BharadwajS Ramalingam
Jan 8, 2019·Applied Microbiology and Biotechnology·László KozákIstván Molnár
Nov 18, 2018·Molecular Genetics and Genomics : MGG·Inoka K HettiarachchigeGerman C Spangenberg
Dec 15, 2017·Journal of Agricultural and Food Chemistry·Julia I BauerEwald Usleber
May 24, 2019·Journal of Natural Products·Ni P AriantariPeter Proksch
Jan 11, 2020·Journal of Agricultural and Food Chemistry·Qiu-Yan SongWen-Jun Wei
Dec 22, 2021·Natural Product Reports·Devon J SchatzSergey V Pronin

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