Lomefloxacin is an effective treatment of experimental bacterial keratitis

Cornea
R P KowalskiY J Gordon

Abstract

Lomefloxacin was evaluated as a potential topical therapy for bacterial keratitis. Lomefloxacin was compared with ciprofloxacin in different rabbit keratitis models. A total of 216 corneas were infected with Staphylococcus aureus (ciprofloxacin-susceptible and -resistant), Streptococcus viridans, Streptococcus pneumoniae, Pseudomonas aeruginosa, and Serratia marcescens and were treated with lomefloxacin (0.3%), ciprofloxacin (0.3% Ciloxan), and the control phosphate-buffered saline (PBS), respectively. The data were analyzed statistically comparing the decrease in the number of recovered viable bacteria. Compared with PBS-treated control corneas, the colony counts for all bacterial isolates were significantly reduced (p < 0.05) after topical treatment with either lomefloxacin or ciprofloxacin. For gram-positive bacteria, lomefloxacin and ciprofloxacin were equally effective. For gram-negative bacteria, lomefloxacin, while effective, was less so than ciprofloxacin under experimental conditions (p < 0.05). Our data, using multiple bacterial keratitis models, suggest that lomefloxacin is promising for therapy of bacterial keratitis. Further clinical studies are needed to expand its use for keratitis therapy.

Citations

Jan 29, 2011·Journal of Biomedicine & Biotechnology·Mary E Marquart
Dec 13, 2006·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·M J KossH M de Kaspar
Oct 15, 2008·Current Eye Research·Moshe SnirRuth Axer-Siegel
Oct 27, 2015·Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association for Ocular Pharmacology and Therapeutics·Regis P KowalskiFrancis S Mah
May 12, 2010·Acta Ophthalmologica·Regis P KowalskiY J Gordon
Aug 4, 2004·American Journal of Ophthalmology·Michelle K RheeY Jerold Gordon
Aug 4, 2004·Current Eye Research·Brett A ThibodeauxRichard J O'Callaghan

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