Long- and medium-chain fatty acid oxidation is increased in exercise-trained human skeletal muscle

Metabolism: Clinical and Experimental
Kim Jong-YeonJ A Houmard

Abstract

The purpose of this study was to test the hypothesis that skeletal muscle fatty acid oxidation is enhanced by increased entry into the mitochondria with exercise training. Muscle was obtained from young ( approximately 24 years) sedentary (n = 13) and endurance-trained (n = 10) volunteers and oxidation studied by measuring (14)CO(2) production from labeled medium-chain (MCFA) or long-chain (LCFA) fatty acids in muscle homogenate preparations. LCFA (palmitate) oxidation was (P <.05) approximately 34% higher in the trained than sedentary subjects (26.9 +/- 3.0 v 17.8 +/- 1.3 nmol CO(2)/g x h). MCFA (octanoate) oxidation was also about 26% higher (P <.05) in the trained subjects (21.7 +/- 2.1 v 16.1 +/- 2.0 nmol CO(2)/g x h). To examine the roles of carnitine-mediated transport and mitochondrial content, we also measured carnitine palmitoyltransferase I (CPT1), carnitine octanoyl transferase (COT), and citrate synthase (CS) activities. CPT1 and CS activity were significantly (P <.05) higher (approximately 25%) in the endurance-trained subjects; there was no difference in COT activity. These data suggest that adaptations at the level of CPT1 and processes distal to this step may contribute to increases in LCFA or MFCA oxidation wit...Continue Reading

Citations

Feb 9, 2006·American Journal of Physiology. Endocrinology and Metabolism·Clinton R BruceDavid J Dyck
Feb 7, 2008·American Journal of Physiology. Endocrinology and Metabolism·Jason R BerggrenJoseph A Houmard
Jul 1, 2014·The Korean Journal of Physiology & Pharmacology : Official Journal of the Korean Physiological Society and the Korean Society of Pharmacology·Kihoon KimKyung-Oh Doh
Dec 14, 2004·International Journal of Obesity and Related Metabolic Disorders : Journal of the International Association for the Study of Obesity·A P Russell
Mar 10, 2007·Scandinavian Journal of Medicine & Science in Sports·C C Zoppi, D V Macedo
Oct 13, 2005·American Journal of Physiology. Endocrinology and Metabolism·Veronic BezaireLawrence L Spriet
Feb 10, 2011·American Journal of Physiology. Endocrinology and Metabolism·Bradley A ClarkTatiana Y Kostrominova
Oct 11, 2012·American Journal of Physiology. Endocrinology and Metabolism·Gina M BattagliaJoseph A Houmard
Dec 14, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Rosemary A SchuhEspen E Spangenburg
Jan 8, 2016·Hormone Molecular Biology and Clinical Investigation·Claire Laurens, Cedric Moro
Apr 3, 2019·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Jonathan P GumucioChristopher L Mendias
Nov 16, 2007·American Journal of Physiology. Endocrinology and Metabolism·Cédric MoroSteven R Smith
Aug 24, 2006·American Journal of Physiology. Endocrinology and Metabolism·K SahlinP K Pedersen
Mar 7, 2013·The Journal of Clinical Endocrinology and Metabolism·Lauren M SparksPatrick Schrauwen
Jul 22, 2011·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Dominik PestaErich Gnaiger
Jul 5, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Céline AguerMary-Ellen Harper
Mar 13, 2020·Journal of Applied Physiology·Mary Elizabeth BaughKevin P Davy
Sep 24, 2020·Nature Reviews. Endocrinology·Andreas Mæchel FritzenBente Kiens
Jul 11, 2008·Medicine and Science in Sports and Exercise·Robert S Lee-YoungGlenn K McConell
Jul 6, 2014·Physiological Reviews·Jaap G Neels, Paul A Grimaldi
Apr 2, 2008·Medicine and Science in Sports and Exercise·Michelle C Venables, Asker E Jeukendrup
Oct 28, 2020·European Journal of Applied Physiology·Daniel A Baur, Michael J Saunders
May 4, 2017·Cell Metabolism·Bret H Goodpaster, Lauren M Sparks
Dec 5, 2016·Journal of the American Medical Directors Association·Mylène Aubertin-LeheudreUNKNOWN LIFE Research Group
Apr 4, 2021·International Journal of Molecular Sciences·Steffen H RaunLykke Sylow
Jun 24, 2004·Nutrition·Asker E Jeukendrup, Sarah Aldred
Nov 10, 2021·The Biochemical Journal·Erik A RichterMark Hargreaves

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