PMID: 11319747Apr 25, 2001Paper

Long- and short-term effects of biological hydrogels on capsule microvascular density around implants in rats

Journal of Biomedical Materials Research
A G RavinB Klitzman

Abstract

Fibrous capsule formation around implants can inhibit solute exchange between implantable devices and the circulation. Parylene-n coated polycarbonate disks surrounded with growth factor reduced Matrigel (MG) or several gelatin-based matrices were implanted intramuscularly into rats for 21 or 50 days. MG supplemented with vascular endothelial growth factor (VEGF) or basic fibroblast growth factor (bFGF) increased capsule microvascular density at 21 days (p < 0.05) when compared to bare parylene-coated polycarbonate disks (control). The increased microvascular density around VEGF- and bFGF-treated implants regressed by 50 days and was no longer significantly different from controls. The microvascular density induced by the gelatin-based matrices was not significantly different from controls at 21 days, but was increased at 50 days (p < 0.05), suggesting a slower, long-term effect. Disks treated with MG and gelatin-based matrices had thinner capsules at 21 days (p < 0.05). By 50 days, the capsule thicknesses around these implants were no longer statistically thinner than controls. The capsule thickness around implants treated with VEGF, bFGF, and essential gelatin-based matrix was thinner than controls at 50 days (p < 0.05). Thes...Continue Reading

References

Oct 1, 1978·Plastic and Reconstructive Surgery·L M VistnesJ Kosek
Nov 1, 1992·Journal of Biomedical Materials Research·D G WallaceG A Ksander
Apr 1, 1988·ASAIO Transactions·J M Anderson
Feb 1, 1971·The Journal of Experimental Medicine·J FolkmanG Williams
Dec 11, 1980·Nature·J Folkman, C Haudenschild
Dec 1, 1995·Science·M FriedlanderD A Cheresh
Apr 22, 1994·Science·P C BrooksD A Cheresh
Apr 1, 1995·American Journal of Clinical Pathology·L Tang, J W Eaton
Jan 1, 1993·The Journal of Surgical Research·A SankT L Tuan
Dec 1, 1995·Journal of Biomedical Materials Research·J H BraukerR C Johnson
Feb 1, 1996·Biomaterials·R F Padera, C K Colton
Nov 22, 1997·Journal of Biomedical Materials Research·A A SharkawyW M Reichert
May 23, 1998·Journal of Biomedical Materials Research·A A SharkawyW M Reichert

❮ Previous
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Citations

May 19, 2004·Academic Radiology·Sith PhongkitkarunChusilp Charnsangavej
Nov 3, 2010·Plastic and Reconstructive Surgery·Evan B KatzelHoward N Langstein
May 28, 2011·Plastic and Reconstructive Surgery·Evan B KatzelHoward N Langstein
Jan 31, 2007·Journal of Biomaterials Science. Polymer Edition·Gianluca GiavaresiRoberto Giardino
Feb 10, 2010·The AAPS Journal·Jacqueline M MoraisDiane J Burgess
Jul 25, 2009·The Journal of Surgical Research·Carlo R Bartoli, John J Godleski
May 18, 2007·Acta Biomaterialia·Anchal KaushivaGuillermo A Ameer
May 22, 2007·Advanced Drug Delivery Reviews·Ge Zhang, Laura J Suggs
Apr 22, 2009·Journal of Cellular and Molecular Medicine·Cristiano SpadaccioJorge A Genovese
Jan 16, 2017·Acta Biomaterialia·Jingzhou YangAli Khademhosseini
Jun 26, 2014·Aesthetic Surgery Journal·Guilherme Berto RoçaIvan Maluf
Jan 20, 2007·Journal of Biomedical Materials Research. Part a·L W NortonW M Reichert
May 20, 2008·Journal of Mathematical Biology·Paul RyanRandy Cohen
Nov 29, 2012·Annals of Plastic Surgery·Kee Cheol ShinMi Kyung Kim
Nov 17, 2005·The International Journal of Artificial Organs·M TschonR Giardino
Aug 21, 2012·Journal of Mathematical Biology·R DjellouliT M Laleg-Kirati

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