Aug 23, 2012

Long-acting antipsychotic drugs for the treatment of schizophrenia: use in daily practice from naturalistic observations

BMC Psychiatry
Giuseppe RossiAndrea Rossi

Abstract

Current guidelines suggest specific criteria for oral or long-acting injectable antipsychotic drugs (LAIs). This review aims to describe the demographic and clinical characteristics of the ideal profile of the patient with schizophrenia treated with LAIs, through the analysis of nonrandomized studies. A systematic review of nonrandomized studies in English was performed attempting to analyze the factors related to the choice and use of LAIs in daily practice. The contents were outlined using the Cochrane methods for nonrandomized studies and the variables included demographic as well as clinical characteristics. The available literature did not allow any statistical analysis that could be used to identify the ideal profile of patients with schizophrenia to be treated with LAIs. Eighty publications were selected and reviewed. Prevalence of LAI use ranged from 4.8% to 66%. The only demographic characteristics that were consistently assessed through retrieved studies were age (38.5 years in the 1970's, 35.8 years in the 1980's, 39.3 years in the 1990's, to 39.5 years in the 2000's) and gender (male > female).Efficacy was assessed through the use of various symptom scales and other indirect measurements; safety was assessed through...Continue Reading

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References

  • References119
  • Citations11

Citations

Mentioned in this Paper

Antipsychotic Effect
Schizophrenia
Controlled-Release Preparations
Hospitalization
Extrapyramidal Sign
Attitude to Health
Antipsychotic Agents
Dyskinesia, Medication-Induced
Observation - Diagnostic Procedure
Anticholinergic Agents

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