Long-Acting C-Peptide and Neuropathy in Type 1 Diabetes: A 12-Month Clinical Trial

Diabetes Care
John WahrenJoseph C Arezzo

Abstract

Lack of C-peptide in type 1 diabetes may be an important contributing factor in the development of microvascular complications. Replacement of native C-peptide has been shown to exert a beneficial influence on peripheral nerve function in type 1 diabetes. The aim of this study was to evaluate the efficacy and safety of a long-acting C-peptide in subjects with type 1 diabetes and mild to moderate peripheral neuropathy. A total of 250 patients with type 1 diabetes and peripheral neuropathy received long-acting (pegylated) C-peptide in weekly dosages of 0.8 mg (n = 71) or 2.4 mg (n = 73) or placebo (n = 106) for 52 weeks. Bilateral sural nerve conduction velocity (SNCV) and vibration perception threshold (VPT) on the great toe were measured on two occasions at baseline, at 26 weeks, and at 52 weeks. The modified Toronto Clinical Neuropathy Score (mTCNS) was used to grade the peripheral neuropathy. Plasma C-peptide rose during the study to 1.8-2.2 nmol/L (low dose) and to 5.6-6.8 nmol/L (high dose). After 52 weeks, SNCV had increased by 1.0 ± 0.24 m/s (P < 0.001 within group) in patients receiving C-peptide (combined groups), but the corresponding value for the placebo group was 1.2 ± 0.29 m/s. Compared with basal, VPT had improved...Continue Reading

References

Jul 1, 1978·The Journal of Clinical Investigation·O K FaberN Rossing
Apr 1, 1974·Journal of Neuropathology and Experimental Neurology·H H SchaumburgP S Spencer
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·R RiglerJ Wahren
Sep 12, 2002·Cellular and Molecular Life Sciences : CMLS·J ShafqatH Jörnvall
Apr 28, 2004·Diabetes Care·Mark J BrownUNKNOWN Zenarest study
May 6, 2004·American Journal of Physiology. Endocrinology and Metabolism·Martin J StevensAnders A F Sima
Nov 19, 2004·Cellular and Molecular Life Sciences : CMLS·Z ZhongA V Chibalin
Mar 26, 2009·Diabetic Medicine : a Journal of the British Diabetic Association·V BrilUNKNOWN mTCNS Study Group
Apr 16, 2009·Diabetes Care·Vera BrilUNKNOWN Ranirestat Study Group
Oct 19, 2010·Diabetic Medicine : a Journal of the British Diabetic Association·B A PerkinsV Bril
Dec 14, 2011·Diabetes Research and Clinical Practice·S C SmithG D H Maclaine
Mar 24, 2012·Diabetes·John WahrenAnders A F Sima
Aug 13, 2013·Handbook of Clinical Neurology·Joseph C ArezzoHerbert H Schaumburg
Sep 25, 2014·American Journal of Physiology. Endocrinology and Metabolism·Gina L C YostenJohn Wahren

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Citations

Nov 5, 2016·Expert Opinion on Emerging Drugs·Nikolaos Papanas, Dan Ziegler
Dec 21, 2016·Journal of Internal Medicine·J Wahren
Apr 5, 2017·Endocrine·Arturo PujiaTiziana Montalcini
Dec 13, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Yanning LiWeigang Luo
Jun 3, 2018·Diabetes/metabolism Research and Reviews·Adeniyi A BorireArun V Krishnan
Aug 31, 2018·Diabetes/metabolism Research and Reviews·Michelle Teodoro AlvesKarina Braga Gomes
Jul 19, 2018·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Hye-Yoon JeonKwon-Soo Ha
Jul 16, 2019·Current Opinion in Neurology·Douglas W Zochodne
Jun 27, 2017·Physiology International·A GhorbaniM T Rajabi-Mashhadi
Jun 27, 2020·Biomedit︠s︡inskai︠a︡ khimii︠a︡·O N Poteryaeva, I F Usynin
Oct 15, 2019·Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association·Jin Ook ChungMin Young Chung
Sep 23, 2020·Cellular and Molecular Life Sciences : CMLS·Michael Landreh, Hans Jörnvall
Sep 27, 2018·Analytical and Bioanalytical Chemistry·Andre D CastiauxDana M Spence
Aug 24, 2018·Diabetes & Metabolism Journal·Ioannis N PetropoulosRayaz A Malik
Jan 12, 2021·Expert Opinion on Investigational Drugs·Marc S Rendell
Dec 15, 2020·Diabetes & Metabolism Journal·Heung Yong JinNigel A Calcutt
Oct 24, 2020·Physiological Research·D VejrazkovaB Bendlova
May 30, 2021·Nature Reviews. Endocrinology·Gordon SloanSolomon Tesfaye
Jun 15, 2021·Frontiers in Endocrinology·Josie CarmichaelMitra Tavakoli
Aug 1, 2020·Current Drug Safety·Johan RøikjerNiels Ejskjaer

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