Long-acting inhaled anticholinergic therapy improves sleeping oxygen saturation in COPD

The European Respiratory Journal
W T McNicholasTiotropium Sleep Study in COPD Investigators

Abstract

Oxygen desaturation occurs during sleep in severe chronic obstructive pulmonary disease (COPD), especially during rapid eye movement (REM) sleep, due to hypoventilation and ventilation-perfusion mismatching, but the possible contribution of airflow limitation is unclear. In a randomised, placebo-controlled, double-blind study of severe, stable COPD patients, the authors compared 4 weeks treatment with a long-acting inhaled anticholinergic agent (tiotropium), taken in the morning (tiotropium-AM), or in the evening (tiotropium-PM), on sleeping arterial oxygen saturation (Sa,O2) and sleep quality. Overnight polysomnography was performed at baseline and after 4 weeks treatment. A total of 95 patients with awake resting arterial oxygen tension < or = 9.98 kPa (75 mmHg) were randomised, with a mean age of 66.4 yrs and mean forced expiratory volume in one second (FEV1) of 32% predicted. A total of 80 patients completed the study, of which 56 fulfilled the polysomnographic criterion of at least 2 h sleep in both sleep study nights and represent the group analysed. Tiotropium significantly improved spirometry compared with placebo. Both tiotropium-AM and tiotropium-PM groups had higher Sa,O2 during REM than placebo (+2.41% and +2.42%, r...Continue Reading

Citations

Dec 8, 2009·Advances in Therapy·Robert A FlynnMarcus P Kennedy
Jun 7, 2005·Primary Care·Robert D Ballard
Dec 21, 2010·Current Opinion in Pulmonary Medicine·Ruth Lee, Walter T McNicholas
Jul 5, 2012·Respirology : Official Journal of the Asian Pacific Society of Respirology·David G McSharryWalter T McNicholas
May 6, 2008·Proceedings of the American Thoracic Society·Samuel KrachmanSteven M Scharf
Dec 1, 2007·International Journal of Chronic Obstructive Pulmonary Disease·David A Lipson
Nov 30, 2007·International Journal of Chronic Obstructive Pulmonary Disease·Oreste MarroneGiuseppe Insalaco
Nov 30, 2007·International Journal of Chronic Obstructive Pulmonary Disease·Paolo Montuschi
Jun 11, 2011·International Journal of Chronic Obstructive Pulmonary Disease·Brian D KentWalter T McNicholas
Feb 12, 2011·International Journal of Chronic Obstructive Pulmonary Disease·Steven M ScharfAriel Tarasiuk
Dec 3, 2011·International Journal of Chronic Obstructive Pulmonary Disease·Domenico Maurizio ToraldoGiuseppe Nicolardi
Jul 16, 2010·International Journal of Chronic Obstructive Pulmonary Disease·Ekaterina S GladyshevaRobert L Owens
Apr 7, 2010·International Journal of Chronic Obstructive Pulmonary Disease·Donald P Tashkin
Mar 2, 2012·Sleep·Rohit BudhirajaStuart F Quan
Apr 22, 2014·International Journal of Chronic Obstructive Pulmonary Disease·Brian Mieczkowski, Michael E Ezzie
Feb 22, 2012·Sleep & Breathing = Schlaf & Atmung·Deuzilane M NunesPedro F C de Bruin
Dec 29, 2009·International Journal of Chronic Obstructive Pulmonary Disease·Steven KestenDonald Tashkin
Jan 1, 2014·Expert Review of Respiratory Medicine·Sophie J Crinion, Walter T McNicholas
May 19, 2010·Expert Review of Respiratory Medicine·A James Mamary, Gerard J Criner
Jun 10, 2009·Expert Opinion on Drug Safety·Pierachille Santus, Fabiano Di Marco
Dec 7, 2006·COPD·Simrit Bhullar, Barbara Phillips
Apr 26, 2011·COPD·Samuel L KrachmanGerard J Criner
Jun 15, 2007·Chest·Kenneth R CaseyLee K Brown
Dec 15, 2006·Chest·Steven KestenStephan Lanes
Dec 1, 2008·Sleep Medicine Clinics·Michael E EzzieJohn G Mastronarde
Nov 21, 2015·Revue de pneumologie clinique·G BrinchaultA Cavaillès
Mar 15, 2016·Respiratory Research·Peter M A CalverleyRichard ZuWallack
Jun 23, 2005·Pulmonary Pharmacology & Therapeutics·Graeme P CurrieOwen J Dempsey
Sep 27, 2015·Sleep & Breathing = Schlaf & Atmung·Izolde BouloukakiSophia E Schiza
Mar 4, 2008·Respiratory Medicine·Gerben StegeYvonne F Heijdra
Jul 13, 2016·The Clinical Respiratory Journal·Marija VukojaMiroslav Ilic
Jul 14, 2009·Chest·Bartolome CelliDonald P Tashkin
Nov 3, 2009·Therapeutic Advances in Respiratory Disease·Amir SharafkhanehMax Hirshkowitz
Feb 17, 2017·Therapeutic Advances in Drug Safety·Mario CazzolaMaria Gabriella Matera
Sep 12, 2013·British Journal of Hospital Medicine·Jing ZhangXin Sun
Oct 3, 2018·Current Opinion in Pulmonary Medicine·Neeraj M Shah, Patrick B Murphy
Jun 24, 2017·The European Respiratory Journal·Helgo MagnussenAnne-Marie Kirsten
May 24, 2019·Respirology : Official Journal of the Asian Pacific Society of Respirology·Patrick B MurphyNicholas Hart
Aug 10, 2016·BMC Pulmonary Medicine·Chih-Hao ChangNing-Hung Chen
Sep 27, 2019·European Respiratory Review : an Official Journal of the European Respiratory Society·Walter T McNicholasLudger Grote

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.