Long-acting muscarinic antagonists (LAMA) added to combination long-acting beta2-agonists and inhaled corticosteroids (LABA/ICS) versus LABA/ICS for adults with asthma

The Cochrane Database of Systematic Reviews
Kayleigh M Kew, Karen Dahri

Abstract

Maintenance treatment with long-acting beta2-agonists and inhaled corticosteroids (LABA/ICS) can relieve asthma symptoms and reduce the frequency of exacerbations, but there are limited treatment options for people who do not gain control on combination LABA/ICS. Long-acting muscarinic antagonists (LAMA) are a class of inhaled drug which have been effective for people with chronic obstructive pulmonary disease and are now becoming available for people with asthma to take alongside their LABA/ICS inhaler. To assess the effects of adding a long-acting muscarinic antagonist (LAMA) to combination long-acting beta2-agonists (LABA) and inhaled corticosteroids (ICS) in adults whose asthma is not well controlled by LABA/ICS. We identified trials from the Cochrane Airways Review Group Specialised Register (CAGR) up to January 2016. We also searched ClinicalTrials.gov, the WHO trials portal, and reference lists of other reviews, and we contacted trial authors for additional information. We included parallel randomised controlled trials (RCTs) of at least 12 weeks' duration. Studies met the inclusion criteria if they compared LAMA as an add-on to LABA/ICS versus LABA/ICS alone for adults with asthma. We included studies reported as full t...Continue Reading

References

Jan 28, 2005·The Cochrane Database of Systematic Reviews·N P AdamsP W Jones
Oct 10, 2008·The Cochrane Database of Systematic Reviews·Nick P AdamsChristopher J Cates
Jul 22, 2009·PLoS Medicine·David MoherUNKNOWN PRISMA Group
Apr 16, 2010·The Cochrane Database of Systematic Reviews·Francine M DucharmeToby J Lasserson
Oct 29, 2010·The New England Journal of Medicine·Stephen P PetersUNKNOWN National Heart, Lung, and Blood Institute Asthma Clinical Research Network
Dec 7, 2010·The Journal of the Royal College of Physicians of Edinburgh·M Lane
Jan 5, 2011·British Journal of Pharmacology·Bart C Moulton, Allison D Fryer
Jun 4, 2011·The Journal of Allergy and Clinical Immunology·Huib A M KerstjensJan A van Noord
Aug 3, 2011·The Journal of Allergy and Clinical Immunology·Eric D BatemanLeonardo M Fabbri
Sep 4, 2012·The New England Journal of Medicine·Huib A M KerstjensEric D Bateman
Oct 18, 2012·Pulmonary Pharmacology & Therapeutics·Makoto YoshidaHiromasa Inoue
Dec 28, 2012·The New England Journal of Medicine·Ricky Turgeon
Mar 29, 2013·British Journal of Clinical Pharmacology·Brian J Lipworth
Oct 3, 2013·The Journal of Allergy and Clinical Immunology·Stephen P PetersUNKNOWN National Heart, Lung, and Blood Institute's Asthma Clinical Research Network
Oct 31, 2013·Respiratory Care·Jing-wei TianXin Chen
Apr 18, 2014·Clinical and Experimental Pharmacology & Physiology·Muhasaparur Ganesan RajanandhKaliappan Ilango
Oct 17, 2014·Chest·Gustavo J Rodrigo, José A Castro-Rodríguez
Feb 13, 2015·The Open Respiratory Medicine Journal·Dhruti PandyaViswanatha Balagopal

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Citations

Jun 9, 2016·Mediators of Inflammation·Zhiyong DongFang Wang
Jan 10, 2017·Journal of Agricultural and Food Chemistry·Yun-Ho KimYoung-Hee Kang
Jan 19, 2017·Expert Opinion on Pharmacotherapy·Neil C Thomson
May 3, 2018·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Jonathan A Bernstein, Reynold Panettieri
Jan 13, 2017·The European Respiratory Journal·Jonathan Grigg
May 31, 2019·International Journal of Molecular Sciences·Elisabetta ZinelluPietro Pirina
Mar 28, 2019·Frontiers in Pediatrics·Li Ping Chung, James Y Paton
Apr 20, 2018·Canadian Respiratory Journal : Journal of the Canadian Thoracic Society·V Madhu Chari, Robert Andrew McIvor
Sep 11, 2018·Expert Opinion on Pharmacotherapy·Neil C Thomson
Feb 10, 2021·Current Allergy and Asthma Reports·Chad R MarionChristopher Barrios
Feb 4, 2021·ERJ Open Research·Gabriel GarcíaMario Rodriguez
Jul 6, 2021·Expert Opinion on Pharmacotherapy·Josuel OraPaola Rogliani
Jul 24, 2018·ACS Medicinal Chemistry Letters·Xianhai HuangAnandan Palani
Nov 17, 2021·Expert Review of Respiratory Medicine·Luis Perez de LlanoJavier Domínguez-Ortega
Dec 1, 2021·Expert Review of Respiratory Medicine·Corrado PelaiaGirolamo Pelaia
Dec 7, 2021·BMC Pulmonary Medicine·Jefferson Antonio Buendía, Diana Guerrero Patiño
Dec 23, 2021·The Journal of Asthma : Official Journal of the Association for the Care of Asthma·Fulvio BraidoPaschalis Steiropoulos

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