PMID: 9177868Jun 1, 1997Paper

Long-bone biomechanics in mice selected for body conformation

Bone
R J Di MassoJ L Ferretti

Abstract

Two lines of mice divergently selected from the control strain (CBi) against the positive phenotypic correlation between body weight (b.w.) and tail (skeletal) length were obtained (CBi/C: high weight, short tail; CBi/L: low weight, long tail). The selected animals showed a different relationship between body and skeletal masses. To compare the adequacy between biomass and load-bearing ability of the skeleton, and to describe the eventual role of bone mechanostat in the production of these changes, cross-sectional and bending properties of both femur diaphyses were determined in CBi, CBi/C, and CBi/L adult mice of both genders. Cortical bone material quality (elastic modulus) was reduced in the selected lines (p < 0.001), significantly less in CBi/C than in CBi/L. In contrast, cross-sectional design (b.w.-adjusted values of moment of inertia, CSMI) was largely improved (p < 0.001), significantly more in CBi/C than in CBi/L. These effects determined a greater stiffness and strength in CBi/C than in CBi/L or CBi weight-paired mice. The elevations of the negative regression lines between elastic modulus and CSMI ("distribution/quality" curves) decreased in the order CBi/C > CBi/L > CBi. Data show that selection improved diaphyseal...Continue Reading

References

Dec 1, 1992·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J L FerrettiJ R Zanchetta
Jan 1, 1989·Journal of Biomechanics·T S Keller, D M Spengler
Jan 1, 1989·Journal of Biomechanics·F Selker, D R Carter
Dec 1, 1986·Calcified Tissue International·A A BiewenerJ E Bertram
Jan 1, 1987·Journal of Biomechanics·D R Carter
Sep 1, 1987·The Anatomical Record·H M Frost
Jan 1, 1973·Journal of Biomedical Materials Research·F W CookeS J Scheifele
Jan 1, 1984·Calcified Tissue International·R T HartK G Heiple
Jan 1, 1984·Archives of Orthopaedic and Trauma Surgery·O Reikerås
Jan 1, 1982·Metabolic Bone Disease & Related Research·H M Frost
Nov 1, 1993·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·J L FerrettiJ R Zanchetta
Jul 1, 1993·Bone·C H Turner, D B Burr
Oct 1, 1993·Bone and Mineral·R J Di Masso, M T Font

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Citations

Jan 1, 1992·Calcified Tissue International·J L FerrettiG Cointry
Sep 20, 2011·Osteoporosis International : a Journal Established As Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA·F GuillerminetA Blais
Apr 8, 2009·Calcified Tissue International·Vanessa YinglingRupali Joshi
Sep 29, 2011·Calcified Tissue International·Tracy BrennanArchana Sanjay
May 4, 2004·Medical Engineering & Physics·David S MargolisJohn A Szivek
Aug 28, 2010·Medicine and Science in Sports and Exercise·McKayla Elle SaineVanessa R Yingling
Sep 22, 1999·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·T JämsäJ Tuukkanen
Oct 5, 2001·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·K J JepsenJ Nadeau
Jul 8, 2008·Biomedizinische Technik. Biomedical Engineering·Romain VoideRalph Müller
Jul 12, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Steven M TommasiniKarl J Jepsen
Apr 13, 2005·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Steven M TommasiniKarl J Jepsen
Jan 24, 2014·Acta ortopedica brasileira·Fernando Tadeu Trevisan FrajacomoSérgio Britto Garcia
Feb 14, 2020·Journal of Anatomy·Miriam Corina VeraGustavo Roberto Cointry

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