Long-Chain Omega-3 Fatty Acids Supplementation Accelerates Nerve Regeneration and Prevents Neuropathic Pain Behavior in Mice

Frontiers in Pharmacology
Rafaela V SilvaAna L P Miranda

Abstract

Fish oil (FO) is the main source of long chain omega-3 polyunsaturated fatty acids (ω-3 PUFAs), which display relevant analgesic and anti-inflammatory properties. Peripheral nerve injury is driven by degeneration, neuroinflammation, and neuronal plasticity which results in neuropathic pain (NP) symptoms such as allodynia and hyperalgesia. We tested the preventive effect of an EPA/DHA-concentrate fish oil (CFO) on NP development and regenerative features. Swiss mice received daily oral treatment with CFO 4.6 or 2.3 g/kg for 10 days after NP was induced by partial sciatic nerve ligation. Mechanical allodynia and thermal hypernociception were assessed 5 days after injury. CFO 2.3 g/kg significantly prevented mechanical and thermal sensitization, reduced TNF levels in the spinal cord, sciatic MPO activity, and ATF-3 expression on DRG cells. CFO improved Sciatic Functional Index (SFI) as well as electrophysiological recordings, corroborating the increased GAP43 expression and total number of myelinated fibers observed in sciatic nerve. No locomotor activity impairment was observed in CFO treated groups. These results point to the regenerative and possibly protective properties of a combined EPA and DHA oral administration after peri...Continue Reading

References

Jul 1, 1994·Journal of Neuroscience Methods·S R ChaplanT L Yaksh
Nov 5, 1999·Brain Research·T A IgnatowskiR N Spengler
Dec 13, 2000·Neuroscience·N M Perkins, D J Tracey
Oct 16, 2002·Glia·Uwe-Karsten Hanisch
Oct 14, 2006·The Journal of Physiology·José A MattaGerard P Ahern
Feb 8, 2007·Current Opinion in Clinical Nutrition and Metabolic Care·Nicolas G Bazan
Jul 27, 2007·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Rhona SeijffersClifford J Woolf
Oct 30, 2007·Nature Neuroscience·Joachim Scholz, Clifford J Woolf
Jan 22, 2008·Journal of Leukocyte Biology·Thiago M CunhaFernando Q Cunha
Jun 11, 2008·Neuromolecular Medicine·S C Dyall, A T Michael-Titus
Apr 25, 2009·BioFactors·Philip C Calder, Parveen Yaqoob
Apr 30, 2009·Annual Review of Neuroscience·Michael CostiganClifford J Woolf
Dec 25, 2009·Fundamental & Clinical Pharmacology·Amteshwar Singh JaggiNirmal Singh
Jan 22, 2010·The Clinical Journal of Pain·Gordon D KoAnnie Hum
Jun 5, 2010·Biological & Pharmaceutical Bulletin·Kazuo NakamotoShogo Tokuyama
Jul 24, 2010·Lancet Neurology·Ralf BaronGunnar Wasner
Jan 20, 2011·Proceedings of the National Academy of Sciences of the United States of America·Andreas HessGeorg Schett
Feb 25, 2011·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Jyothi M VeigasGabriel Fernandes
Sep 1, 2011·Journal of Neuroinflammation·Andrew D GaudetMatt S Ramer
Oct 4, 2011·Trends in Neurosciences·Ru-Rong JiCharles N Serhan
Oct 22, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Chul-Kyu ParkRu-Rong Ji
Nov 8, 2011·Journal of Neuroscience Research·Maria Antonietta Ajmone-CatLuisa Minghetti
Jan 13, 2012·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Stacy J GladmanAdina T Michael-Titus
Jul 7, 2012·British Journal of Clinical Pharmacology·Philip C Calder
Nov 6, 2012·Neurobiology of Disease·Siew-Na LimAdina T Michael-Titus
Jun 26, 2013·British Journal of Anaesthesia·A Ellis, D L H Bennett
Jun 4, 2015·European Journal of Pharmacology·Marc-Olivier TrépanierRichard P Bazinet
Sep 12, 2015·Annals of the Rheumatic Diseases·Catherine L HillGraeme Jones
Sep 18, 2015·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zhuo-Hao LiuAdina T Michael-Titus

❮ Previous
Next ❯

Citations

Dec 27, 2019·The Journal of Pharmacy and Pharmacology·Santiago R UndaCarlos H Laino
Sep 11, 2019·Nutrition and Health·Lina BegdacheMaher Chaar
Nov 23, 2019·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Pascual TorresVictòria Ayala
Nov 9, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Luísa Teixeira-SantosDora Pinho
May 10, 2021·Clinical Therapeutics·Ioannis N PetropoulosRayaz A Malik
Jul 25, 2021·International Journal of Molecular Sciences·Marwa El SouryGiulia Ronchi
Aug 31, 2021·Frontiers in Pharmacology·Alessandro LeutiMauro Maccarrone

❮ Previous
Next ❯

Methods Mentioned

BETA
enzyme-linked immunosorbant assay

Key Resources (RRID) Mentioned

AB_640874
AB_2258513
AB_2223228
AB_2223041

Software Mentioned

GraphPad Prism
LabChart
ImageJ

Related Concepts

Related Feeds

Anti-inflammatory Treatments

A drug or substance that reduces inflammation (redness, swelling, and pain) in the body. Anti-inflammatory agents block certain substances in the body that cause inflammation and swelling. Discover the latest research on anti-inflammatory treatments here

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.