Long-circulating perfluorooctyl bromide nanocapsules for tumor imaging by 19FMRI

Biomaterials
Odile DiouE Fattal

Abstract

PLGA-PEG nanocapsules containing a liquid core of perfluorooctyl bromide were synthesized by an emulsion-evaporation process and designed as contrast agents for (19)F MRI. Physico-chemical properties of plain and PEGylated nanocapsules were compared. The encapsulation efficiency of PFOB, estimated by (19)F NMR spectroscopy, is enhanced when using PLGA-PEG instead of PLGA. PLGA-PEG nanocapsule diameter, measured by Dynamic Light Scattering is around 120 nm, in agreement with Transmission Electron microscopy (TEM) observations. TEM and Scanning Electron Microscopy (SEM) reveal that spherical core-shell morphology is preserved. PEGylation is further confirmed by Zeta potential measurements and X-ray Photoelectron Spectroscopy. In vitro, stealthiness of the PEGylated nanocapsules is evidenced by weak complement activation. Accumulation kinetics in the liver and the spleen was performed by (19)F MRI in mice, during the first 90 min after intravenous injection. In the liver, plain nanocapsules accumulate faster than their PEGylated counterparts. We observe PEGylated nanocapsule accumulation in CT26 xenograft tumor 7 h after administration to mice, whereas plain nanocapsules remain undetectable, using (19)F MRI. Our results validate t...Continue Reading

References

Mar 13, 1986·Biochimica Et Biophysica Acta·P Child, J Rafter
Aug 1, 1996·European Journal of Pediatrics·T H Shaffer, M R Wolfson
Aug 1, 2000·Colloids and Surfaces. B, Biointerfaces·J H JeongT G Park
Jan 1, 1954·Transactions of the New York Academy of Sciences·E H MOSBACHF E KENDALL
Mar 17, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Moses O OyewumiRussell J Mumper
Nov 30, 2004·Journal of Controlled Release : Official Journal of the Controlled Release Society·Miechel L T ZweersJan Feijen
Jul 26, 2005·Nature Biotechnology·Eric T AhrensPenelope A Morel
Apr 19, 2006·Langmuir : the ACS Journal of Surfaces and Colloids·E PisaniE Fattal
Jun 17, 2006·Journal of Biomedical Materials Research. Part a·A VonarbourgJ P Benoit
Dec 13, 2006·International Journal of Pharmaceutics·Carolina Gómez-GaeteElias Fattal
Sep 25, 2007·Drug Development and Industrial Pharmacy·Gautam Dalwadi, Vivian Bruce Sunderland
Sep 27, 2008·Journal of Cardiovascular Magnetic Resonance : Official Journal of the Society for Cardiovascular Magnetic Resonance·Emily A WatersSamuel A Wickline
Nov 4, 2008·Proceedings of the National Academy of Sciences of the United States of America·Shanta DharStephen J Lippard
Apr 4, 2009·Nanomedicine : Nanotechnology, Biology, and Medicine·Jason ParkTarek M Fahmy
Oct 2, 2009·Langmuir : the ACS Journal of Surfaces and Colloids·Charles SansonSébastien Lecommandoux
Mar 10, 2010·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Sherief EssaPatrice Hildgen
Jun 23, 2010·Biomaterials·Yusuke ArimaHiroo Iwata
Aug 12, 2010·Artificial Organs·Camila Irene Castro, Juan Carlos Briceno
Nov 26, 2010·Biomaterials·Christine VauthierBernard Cabane
Jun 22, 2011·Advanced Drug Delivery Reviews·S Moein MoghimiA Christy Hunter

❮ Previous
Next ❯

Citations

Jun 8, 2013·Journal of the American Chemical Society·Todd K StevensAlexander Pines
Apr 29, 2014·Journal of Controlled Release : Official Journal of the Controlled Release Society·Jean-Michel RabanelXavier Banquy
Dec 18, 2013·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Odile DiouNicolas Tsapis
Oct 25, 2012·Expert Opinion on Drug Delivery·Odile DiouElias Fattal
Sep 11, 2012·Biomaterials·Mangala SrinivasMathias Hoehn
Nov 29, 2015·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Benjamin NotteletJean Coudane
Sep 1, 2015·Wiley Interdisciplinary Reviews. Nanomedicine and Nanobiotechnology·Brittany L BanikJustin L Brown
Sep 15, 2015·Physical Chemistry Chemical Physics : PCCP·Ksenia AstafyevaNicolas Taulier
Mar 26, 2013·Oncoimmunology·Anthony BalducciJelena M Janjic
Dec 3, 2014·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Donato CoscoMassimo Fresta
Apr 9, 2016·Langmuir : the ACS Journal of Surfaces and Colloids·Baptiste SarrazinPatrick Guenoun
May 3, 2016·Nanomedicine : Nanotechnology, Biology, and Medicine·Hieu Vu-QuangJørgen Kjems
Sep 7, 2016·European Journal of Pharmaceutics and Biopharmaceutics : Official Journal of Arbeitsgemeinschaft Für Pharmazeutische Verfahrenstechnik E.V·Tanguy BoissenotNicolas Tsapis
Oct 21, 2014·Chemical Reviews·Ilaria TirottaGiuseppe Resnati
Feb 22, 2018·Journal of Drug Delivery·Sheikh Tasnim JahanAzita Haddadi
Dec 18, 2018·Pharmaceutical Development and Technology·Samer R AbulateefehAlaaldin M Alkilany
Dec 6, 2018·Contrast Media & Molecular Imaging·Arifudin AchmadYoshito Tsushima
Dec 11, 2019·Contrast Media & Molecular Imaging·Jabadurai Jayapaul, Leif Schröder
Apr 14, 2018·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Alison L TaskerSimon Biggs
Mar 14, 2014·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Kévin ZimnyOlivier Mondain-Monval
Jan 20, 2021·Nanoscale·Lucie JamgotchianEric Doris
Oct 30, 2020·Nanomaterials·Natalia ŁopuszyńskaWładysław P Węglarz

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cajal Bodies & Gems

Cajal bodies or coiled bodies are dense foci of coilin protein. Gemini of Cajal bodies, or gems, are microscopically similar to Cajal bodies. It is believed that Cajal bodies play important roles in RNA processing while gems assist the Cajal bodies. Find the latest research on Cajal bodies and gems here.

Antibody-Dependent Cell Cytotoxicity

Antibody-dependent cellular toxicity refers to the lysis of a target cell by a non-sensitized effector cell of the immune system as a result of antibodies binding to the target cell membrane and engaging the Fc receptors on the immune effector cells. Find the latest research on antibody-dependent cellular toxicity here.