Long-distance energy transfer photosensitizers arising in hybrid nanoparticles leading to fluorescence emission and singlet oxygen luminescence quenching

Photochemical & Photobiological Sciences : Official Journal of the European Photochemistry Association and the European Society for Photobiology
Aymeric SèveC Frochot

Abstract

This paper presents energy transfer occurring in small organically modified core-shell nanoparticles (core lanthanide oxide, shell polysiloxane) (diameter < 10 nm) conjugated with photosensitizers designed for photodynamic therapy applications. These nanoparticles covalently encapsulate a photosensitizing PDT drug in different concentrations. Stable dispersions of the nanoparticles were prepared and the photophysical properties of the photosensitizers were studied and compared to those of the photosensitizers in solution. Increasing the photosensitizer concentration in the nanoparticles was not found to cause any changes in the absorption properties while fluorescence and singlet oxygen quantum yields decreased. As a possible explanation, we have suggested that both long distance energy transfer such as FRET and self-quenching could occur into the nanoparticles. A simple "trend" model of this kind of energy transfer complies with results of experiments on steady state fluorescence and singlet oxygen luminescence.

References

Feb 1, 1989·Journal of Photochemistry and Photobiology. B, Biology·L E BennettR W Henderson
Jun 2, 2001·Journal of Photochemistry and Photobiology. B, Biology·X DamoiseauM Hoebeke
Dec 15, 2005·Nano Letters·Jason R McCarthyRalph Weissleder
Jan 21, 2006·Journal of Controlled Release : Official Journal of the Controlled Release Society·Loraine TirandMuriel Barberi-Heyob
Jul 20, 2006·Cancer Research·Yongdoo ChoiChing-Hsuan Tung
Apr 3, 2007·Journal of the American Chemical Society·Jean-Luc BridotOlivier Tillement
Jun 26, 2007·Langmuir : the ACS Journal of Surfaces and Colloids·Dayane B TadaLiane M Rossi
Jul 25, 2007·Photochemistry and Photobiology·Marino A CampoNorbert Lange
Sep 23, 2008·Trends in Biotechnology·Denise BechetMuriel Barberi-Heyob
Oct 7, 2008·Langmuir : the ACS Journal of Surfaces and Colloids·Liane M RossiMaurício S Baptista
Feb 12, 2009·ACS Nano·Anne-Charlotte FaureOlivier Tillement
Mar 12, 2009·Chemical Communications : Chem Comm·David BrevetJean-Olivier Durand
Apr 3, 2010·Journal of Nanoscience and Nanotechnology·Dayane B TadaMauricio S Baptista
Sep 23, 2010·Current Medicinal Chemistry·M VerhilleC Frochot
Jul 6, 2011·Nanomedicine·Pierre CouleaudCéline Frochot

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Citations

Oct 30, 2014·Frontiers in Chemistry·Daniel R CooperJay L Nadeau
May 16, 2017·Physical Chemistry Chemical Physics : PCCP·Nerea Epelde-ElezcanoSylvie Lacombe

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