Long distance pathways of diffusion for dextran along fibre bundles in brain. Relevance for volume transmission

Neuroreport
B BjelkeK Fuxe

Abstract

Texas Red-labelled dextran with a mol. wt of 3000 g mol-1, a marker for the extracellular space, was injected unilaterally into the neostriatum of adult rats (0.3-30 micrograms microliter-1) and its distribution evaluated 1 min to 5 h later. Diffusion in the neuropil was observed with clearance starting after 30 min. After 10-15 min strong labelling along the myelinated fibre bundles was observed in the entire neostriatum. After about 20 min the labelling along the fibres reached into the corpus callosum and the overlaying deep layers of the cerebral cortex. A marked cellular uptake and accumulation of labelled dextran was found in putative perivascular pericytes. Thus, in the living brain preferential extracellular fluid pathways for diffusion exist, especially along fibre bundles, which allow the exchange of chemical signals between two distant regions. These may represent extracellular fluid pathways for volume transmission.

References

Feb 1, 1990·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·K MossbergB Ulfhake
Jan 1, 1989·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·B Bjelke, A Seiger
Jan 1, 1987·Annual Review of Biochemistry·A G Gilman
Aug 15, 1994·Neuroreport·P Bach-y-Rita

❮ Previous
Next ❯

Citations

Apr 26, 2001·NMR in Biomedicine·K NicolayM J Kruiskamp
Jul 20, 2005·Pharmaceutical Research·Conrad E JohansonAndrew Baird
May 16, 2013·Chinese Journal of Integrative Medicine·Wei-Bo ZhangFuxe Kjell
Jul 4, 1998·Brain Research. Brain Research Reviews·M ZoliL F Agnati
Jun 4, 1998·Trends in Neurosciences·C Nicholson, E Syková
Aug 14, 2012·Fluids and Barriers of the CNS·Jan G VeeningHenk P Barendregt
May 12, 2012·Brain Research·Rehana K Leak, Robert Y Moore
May 25, 2010·Physiology & Behavior·Jan G VeeningHenk P Barendregt
Oct 27, 2009·Progress in Neurobiology·Kjell FuxeLuigi Agnati
Mar 26, 2016·Seminars in Cell & Developmental Biology·Lawrence EdelsteinJohn Smythies
May 27, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Dasiel O Borroto-EscuelaKjell Fuxe
Apr 21, 2005·The Journal of Biological Chemistry·Andy Y ShihTimothy H Murphy
Dec 29, 2000·Molecular Psychiatry·L VitkovicC Jacque
Oct 27, 1998·Chronobiology International·J LeSauter, R Silver
Feb 1, 1997·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·I Vorísek, E Syková
Sep 5, 2020·Microscopy and Microanalysis : the Official Journal of Microscopy Society of America, Microbeam Analysis Society, Microscopical Society of Canada·Bai XuebingChen Qiusheng
Aug 1, 1997·Journal of Neurophysiology·I Vorísek, E Syková

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Brain Barrier

The blood brain barrier is a border that separates blood from cerebrospinal fluid. Discover the latest search on this highly selective semipermeable membrane here.