Long-distance running modulates the expression of leucocyte and endothelial adhesion molecules

Scandinavian Journal of Immunology
H G Nielsen, T Lyberg

Abstract

There still exist many unanswered questions whether physical exercise is beneficial or harmful to the immune system. The 'open-window' post-exercise hypothesis states that athletes are more susceptible to infections after exercise, but there is a need for further elucidation. The aim of the present study was to investigate the effect of long-distance running on leucocyte expression of selected adhesion molecules as well as the plasma levels of soluble leucocyte- and endothelium-derived adhesion molecules. Twenty-seven men participating in Oslo marathon together with 16 entrants (eight men and eight women) in the Oslo half-marathon were recruited to this study. Venous blood was collected before and immediately after the races for analysing the leucocyte expression of CD62L, CD11b and CD14 with the help of flow cytometry, and plasma concentrations of soluble (s) sE-selectin, sL-selectin, sP-selectin, sVCAM-1, sICAM-1 and sCD14 were assessed by means of enzyme-linked immunosorbent assays. A significant increase of leucocyte CD11b expression was observed following both races, compared to the pre-race situation. Monocyte CD14 expression increased only after the marathon race. After both races, CD62L expression was significantly lowe...Continue Reading

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Citations

Sep 20, 2012·European Journal of Applied Physiology·Dace ReihmaneFlemming Dela
Nov 8, 2007·Current Allergy and Asthma Reports·Karin C Lødrup Carlsen, Berit Granum
Nov 28, 2006·British Journal of Sports Medicine·Anatoli PetridouVassilis Mougios
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May 19, 2012·Scandinavian Journal of Immunology·D ReihmaneP Tretjakovs
Dec 25, 2015·British Journal of Sports Medicine·Cyril MartinPhilippe Connes
Feb 6, 2007·Medicine and Science in Sports and Exercise·Hilde Grindvik NielsenTorstein Lyberg
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May 21, 2013·American Journal of Physical Medicine & Rehabilitation·Haemi JeeYoung-Joo Kim
Nov 22, 2019·Applied Physiology, Nutrition, and Metabolism = Physiologie Appliquée, Nutrition Et Métabolisme·Garrett W HillMatthew R Kuennen
Jun 29, 2018·Interventional Medicine & Applied Science·Mehdi MogharnasiHossein TaheriChadorneshin
Jun 17, 2020·European Journal of Applied Physiology·Jules A A C HeubergerAdam F Cohen
Sep 22, 2020·PloS One·Leandro BorgesElaine Hatanaka
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Oct 24, 2020·The Journal of Sports Medicine and Physical Fitness·Alexander L Plakida

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