PMID: 8592194Nov 1, 1995Paper

Long-duration self-sustained epileptiform activity in the hippocampal-parahippocampal slice: a model of status epilepticus

Journal of Neurophysiology
A RafiqD A Coulter

Abstract

1. Combined hippocampal-parahippocampal slices were employed to study the development of complex epileptiform discharges after Schaeffer collateral stimulation in vitro. With repeated stimulation, slices generated several different types of epileptiform discharges, which were temporally linked to the preceding stimulus, and predictable in their progression. The first epileptiform discharge to be elicited by stimulation was a primary afterdischarge, which began immediately after the stimulation train and progressed with repeated stimulation until it had peaked in amplitude and duration by the third to fifth stimulus train. After development of the primary afterdischarge, a secondary afterdischarge began to appear, with a 2- to 5-min latency after the third to sixth stimulation train, and progressed in amplitude and duration with repeated stimulation, sometimes to durations > 30 min. 2. After development of the secondary afterdischarge, 65-70% of rostral slices triggered long-duration, spontaneous self-sustained activity. This activity consisted of repeated spontaneous 3- to 5-min duration ictallike discharges with a short interval (< 15 min between events), lasting for hours in many cases. These discharges were similar to activi...Continue Reading

Citations

Dec 22, 1999·Journal of Neurophysiology·M Steriade, F Amzica
Jan 1, 2011·The Neurohospitalist·Edward M Manno
Aug 3, 2005·Epilepsia·Houman KhosravaniPeter L Carlen
Jul 27, 2000·Annals of the New York Academy of Sciences·H E Scharfman
Jun 11, 2004·Chaos·Jose L Perez Velazquez, Houman Khosravani
Nov 19, 2011·Expert Review of Neurotherapeutics·Hussam Seif-Eddeine, David M Treiman
Dec 14, 2011·Journal of Neurophysiology·Mogens Andreasen, Steen Nedergaard
Nov 9, 2006·The Journal of Pharmacology and Experimental Therapeutics·Paulianda J JonesManoj K Patel
Sep 28, 1998·The European Journal of Neuroscience·C E Elger, K Lehnertz
Nov 23, 2007·Epilepsia·Kara Buehrer KileDominique M Durand
Jan 5, 2002·Annals of Neurology·V SanthakumarI Soltesz

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