Long Exercise Test in Periodic Paralysis: A Bayesian Analysis

Muscle & Nerve
Daniel B SimmonsE L Logigian

Abstract

The long exercise test (LET) is used to assess the diagnosis of periodic paralysis (PP), but LET methodology and normal "cutoff" values vary. To determine optimal LET methodology and cutoffs, we reviewed LET data (abductor digiti minimi motor response amplitude, area) from 55 patients with PP (32 genetically definite) and 125 controls. Receiver operating characteristic curves were constructed, and area under the curve (AUC) was calculated to compare (1) peak-to-nadir versus baseline-to-nadir methodologies and (2) amplitude versus area decrements. Using bayesian principles, we calculated optimal cutoff decrements that achieved 95% posttest probability of PP for various pretest probabilities (PreTPs). AUC was highest for peak-to-nadir methodology and equal for amplitude and area decrements. For PreTP ≤ 50%, optimal decrement cutoffs (peak-to-nadir) were > 40% (amplitude) or > 50% (area). For confirmation of PP, our data endorse the diagnostic utility of peak-to-nadir LET methodology using 40% amplitude or 50% area decrement cutoffs for PreTP ≤50%. Muscle Nerve 59:47-54, 2019.

References

Oct 1, 1986·Muscle & Nerve·P G McManisJ R Daube
Jul 7, 2000·Muscle & Nerve·T KuntzerG Monnier
Feb 18, 2004·Journal of Neurology, Neurosurgery, and Psychiatry·C H TenganG M Manzano
Sep 25, 2004·Annals of Neurology·Emmanuel FournierBertrand Fontaine
Nov 10, 2004·Neurology·T M MillerL J Ptácek
Oct 1, 2005·Brain : a Journal of Neurology·S L VenanceUNKNOWN CINCH investigators
Mar 10, 2011·Annals of Neurology·S Veronica TanMichael G Hanna
May 30, 2013·Muscle & Nerve·Eric L LogigianDavid N Herrmann
Feb 13, 2016·Neurology·Valeria A SansoneUNKNOWN Muscle Study Group
Jul 26, 2017·Journal of Clinical Neurophysiology : Official Publication of the American Electroencephalographic Society·Jiaoting JinJingxia Dang
Nov 11, 2017·Muscle & Nerve·Jeffrey M StatlandRobert C Griggs

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Citations

Aug 3, 2018·Muscle & Nerve·Barbara E Shapiro, David C Preston
Nov 25, 2021·Muscle & Nerve·Ana RibeiroDoreen Fialho

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