Long graft cold ischemia time is associated with increased arterial stiffness in renal transplant recipients

Transplantation Proceedings
Paweł StrózeckiJacek Manitius

Abstract

Increased pulse wave velocity (PWV), an indicator of arterial stiffness, is associated with greater cardiovascular risk among renal transplant recipients. PWV depends on recipient-related factors and, as shown in recent studies, also on donor age. There is a lack of information whether graft-related factors influence arterial function in recipients. Graft cold ischemia time (CIT) significantly influences renal transplant outcomes. It was shown in an experimental model of aortic grafting that increased CIT promoted arteriosclerosis. The aim of the present study was to evaluate the relationship between renal graft CIT and PWV. Carotid-femoral PWV were measured in 103 cadaveric kidney recipients of mean age 45 +/- 12 years. We analyzed clinical data of recipient and donor ages, genders, body mass index, blood pressure, CIT, delayed graft function, and type of immunosuppressive therapy to compare patients with CIT < 24 (n = 24) versus CIT > or = 24 hours (n = 79). PWV was lower among patients with shorter CIT (8.3 +/- 1.6 vs 9.2 +/- 2.0 respectively; P < .05). No significant differences were observed between the groups regarding donor and recipient ages, blood pressure, glomerular filtration rate, or immunosuppressive and cardiovas...Continue Reading

References

Jan 23, 1999·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·M Pérez FontánF Valdés
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Jun 26, 2002·Kidney International·Charles J FerroCharles R V Tomson
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Mar 9, 2005·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Ming-Cheng WangJeng-Jong Huang
Oct 4, 2007·JAMA : the Journal of the American Medical Association·Anna A AhimastosBronwyn A Kingwell
Feb 1, 2008·Journal of the American Society of Nephrology : JASN·Michel DelahousseJean-Philippe Haymann

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Citations

Aug 6, 2013·Journal of Atherosclerosis and Thrombosis·Ozkan GungorErcan Ok
Sep 21, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·R JoannidèsI Etienne

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