Long intergenic non-coding RNA 00152 promotes tumor cell cycle progression by binding to EZH2 and repressing p15 and p21 in gastric cancer

Oncotarget
Wen-Ming ChenYong-Qian Shu

Abstract

Long noncoding RNAs (lncRNAs) play important regulatory roles in several human cancers. Integrated analysis revealed that expression of long intergenic non-coding RNA 152 (LINC00152) was significantly upregulated in gastric cancer (GC). Further analysis in a cohort of 97 GC patients revealed that LINC00152 expression was positively correlated with tumor invasion depth, lymph node metastasis, higher TNM stage, and poor survival. Gene set enrichment analysis revealed that cell proliferation and cell cycle progression were increased in patients with high LINC00152 expression. In both GC cell lines and xenograft systems, LINC00152 overexpression facilitated GC cell proliferation by accelerating the cell cycle, whereas LINC00152 knockdown had the opposite effect. Moreover, by binding to enhancer of zeste homolog 2 (EZH2), LINC00152 promotes GC tumor cell cycle progression by silencing the expression of p15 and p21. These findings suggest that LINC00152 may play contribute to the progression of GC and may be an effective therapeutic target.

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Citations

May 31, 2016·Clinical Epigenetics·Koraljka Gall TrošeljDjurdjica Ugarkovic
Jun 1, 2017·International Journal of Molecular Sciences·Ke-Sin YanRuey-Hwang Chou
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Datasets Mentioned

BETA
GSE15459
GSE26253
GSE13911

Methods Mentioned

BETA
PCR
transfection
xenograft
Flow cytometry
RIP
pull-down
immunoprecipitation
ChIP
electrophoresis

Software Mentioned

GraphPad
Cell Quest
BLAST
GSEA
GENCODE
Quantity One
SPSS
Gene Set Enrichment Analysis ( GSEA )
GraphPad Prism
MeV

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