Long interspersed nuclear element-1 methylation status in the circulating DNA from blood of patients with malignant and chronic inflammatory lung diseases.

European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)
Anastasia A PonomaryovaNadezhda V Cherdyntseva

Abstract

Along with other malignant diseases, lung cancer arises from the precancerous lung tissue state. Aberrant DNA methylation (hypermethylation of certain genes and hypomethylation of retrotransposons) is known as one of the driving forces of malignant cell transformation. Epigenetic changes were shown to be detectable in DNA, circulating in the blood (cirDNA) of cancer patients, indicating the possibility to use them as cancer markers. The current study is the first to compare the Long interspersed nuclear element-1 (LINE-1) methylation level in the blood from lung cancer patients before treatment versus different control groups as healthy subjects, patients with bronchitis and patients with chronic obstructive pulmonary disease (COPD). The concentration of LINE-1 methylated fragments, region 1 (LINE-1 methylated, LINE-1-met) was estimated by quantitative methyl-specific PCR. The total concentration of the circulating LINE-1 copies was measured by qPCR specific for LINE-1 region 2, which was selected due to its CpG methylation-independent sequence (LINE-1-Ind). Both LINE-1 methylation level and LINE-1 methylation index (LINE-1-met/LINE-1-Ind ratio) was decreased in lung cancer patients compared with the joint control group (health...Continue Reading

References

Dec 6, 2005·Nucleic Acids Research·Daniel J WeisenbergerPeter W Laird
May 22, 2009·Epigenetics : Official Journal of the DNA Methylation Society·Thomas VaissièreZdenko Herceg
Aug 28, 2013·COPD·Victor KimUNKNOWN National Emphysema Treatment Trial Research Group
Aug 28, 2016·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Ildar V GainetdinovTatyana L Azhikina
Feb 12, 2017·Clinical Chemistry·Daniel ArdeljanKathleen H Burns
Jun 20, 2017·Lung Cancer : Journal of the International Association for the Study of Lung Cancer·Andrea ImperatoriDaniela Furlan
Aug 19, 2017·Pulmonary Pharmacology & Therapeutics·Angelo ZinelluPietro Pirina
Jan 23, 2018·Therapeutic Advances in Respiratory Disease·Ann D MorganJennifer K Quint
Feb 19, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Afsaneh LavasanifarSaeed A Jortani
Mar 15, 2019·Experimental Biology and Medicine·Kenneth S RamosIrma N Ramos

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Citations

Sep 24, 2020·CA: a Cancer Journal for Clinicians·Michelle C TurnerAaron Cohen
Sep 6, 2020·Cells·Anastasia A PonomaryovaTatyana L Azhikina
Jun 21, 2021·International Archives of Occupational and Environmental Health·Ibrahim IssahJulius N Fobil

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