Long-lasting analgesic and neuroprotective action of the non-benzodiazepine anxiolytic etifoxine in a mouse model of neuropathic pain.

Neuropharmacology
Nisrine KamounPierrick Poisbeau

Abstract

Neuropathic pain is frequently associated with anxiety and major depressive disorders, which considerably impact the overall patient experience. Favoring GABAergic inhibition through the pain matrix has emerged as a promising strategy to restore proper processing of nociceptive and affective information in neuropathic pain states. In this context, the non-benzodiazepine anxiolytic etifoxine (EFX), known to amplify GABAergic inhibition through positive modulation of GABAA receptors and neurosteroidogenesis, presents several advantages. Therefore, we sought to investigate the preclinical therapeutic potential of EFX on the somatosensory and affective components of neuropathic pain. Here, we used a murine model in which neuropathic pain was induced by the implantation of a compressive cuff around the sciatic nerve (mononeuropathy). We showed that the intraperitoneal EFX treatment for five consecutive days (50 mg/kg) relieved mechanical allodynia in a sustained manner. Besides its effect on evoked mechanical hypersensitivity, EFX also alleviated aversiveness of ongoing pain as well as anxiodepressive-like consequences of neuropathic pain following cuff-induced mononeuropathy. This effect was also seen 12 weeks after induction of th...Continue Reading

References

Jan 1, 1991·Pharmacology, Biochemistry, and Behavior·K Njung'e, S L Handley
Jul 1, 1994·Journal of Neuroscience Methods·S R ChaplanT L Yaksh
Oct 29, 1996·Proceedings of the National Academy of Sciences of the United States of America·D P UzunovA Guidotti
Nov 11, 1999·Proceedings of the National Academy of Sciences of the United States of America·L D Griffin, S H Mellon
Dec 2, 2004·Brain Research. Brain Research Reviews·Horacio Vanegas, Hans-Georg Schaible
Jun 2, 2005·Pain·David J GoldsteinSmriti Iyengar
Aug 5, 2005·Current Treatment Options in Neurology·Raphael J Leo
Dec 16, 2005·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Gustav AkkSteven Mennerick
Jan 4, 2006·Pharmacology, Biochemistry, and Behavior·Marc VerleyeJean-Marie Gillardin
Jun 10, 2006·Trends in Pharmacological Sciences·Juan A MicóAlain Eschalier
Nov 17, 2007·European Journal of Pain : EJP·Malika BenbouzidMichel Barrot
Dec 17, 2008·Proceedings of the National Academy of Sciences of the United States of America·Christelle GirardGhislaine Schweizer-Groyer
Aug 29, 2009·The Journal of Pain : Official Journal of the American Pain Society·Alban Latremoliere, Clifford J Woolf
Sep 29, 2009·Nature Neuroscience·Tamara KingFrank Porreca
Jul 24, 2010·Lancet Neurology·Ralf BaronGunnar Wasner
Jun 16, 2011·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Florian T NickelChristian Maihöfner
Sep 6, 2011·Biological Psychiatry·Ipek YalcinMichel Barrot
Sep 29, 2011·Journal of Neuroendocrinology·C GirardG Groyer
Feb 3, 2012·Physiological Reviews·Hanns Ulrich ZeilhoferGonzalo E Yévenes
Jan 1, 2011·Frontiers in Endocrinology·Patrizia LongoneRainer Rupprecht
Jul 21, 2012·Advances in Protein Chemistry and Structural Biology·Samina SalimMohammad Asghar
Aug 3, 2012·Biological Psychiatry·Cristina Alba-DelgadoEsther Berrocoso
Sep 12, 2012·Journal of Molecular Endocrinology·Silvia GiattiBarbara Viviani
Mar 19, 2013·European Journal of Pharmacology·Gordon MunroNaheed R Mirza
Jul 6, 2014·Frontiers in Cellular Neuroscience·Pierrick PoisbeauMichael Schumacher
Sep 26, 2014·Nature Neuroscience·Edita Navratilova, Frank Porreca
Jan 13, 2015·Lancet Neurology·Nanna B FinnerupMark Wallace
Mar 7, 2015·Progress in Molecular Biology and Translational Science·Steven A Prescott

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