Jul 11, 1980

Long-lasting depletion of striatal dopamine by a single injection of amphetamine in iprindole-treated rats

Science
R W Fuller, S K Hemrick-Luecke

Abstract

A single injection of amphetamine given to rats treated concurrently with iprindole so that they could not metabolize the amphetamine by para-hydroxylation resulted in a decrease in the concentration of striatal dopamine 1 week later. The decrease was antagonized by amfonelic acid, an inhibitor of uptake into dopamine neurons. The long-lasting depletion of cerebral dopamine by amphetamine may be analogous to the depletion of cerebral serotonin by halogenated derivatives of amphetamine.

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Mentioned in this Paper

Amphetamine
Derivatives
Serotonin Measurement
Serotonin
Tissue Specificity
Thyramine
Brain
Lentiform Nucleus Structure
Uptake
Norepinephrine, (+, -)-Isomer

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