Jan 6, 1980

Long-lasting depletions of striatal dopamine and loss of dopamine uptake sites following repeated administration of methamphetamine

Brain Research
G C WagnerJ Westley


Repeated administration of high doses of methamphetamine produced long-term decreases in dopamine (DA) levels and in the number of DA uptake sites in the rat striatum. These two effects were dose-related and did not appear to be due to the continued presence of drug in striatal tissue. Long-lasting depletions induced by methamphetamine were selective for striatal DA neurons since norepinephrine (NE) levels in all of the rat brain regions examined were not changed on a long-term basis by methamphetamine treatments. Supersensitivity of DA receptors did not accompany the loss of striatal DA and its uptake sites.

Mentioned in this Paper

Striatonigral Degeneration, Infantile (Disorder)
Congenital Abnormal Synostosis
Lentiform Nucleus Structure
Dopamine Uptake
Methamphetamine Measurement
Norepinephrine, (+, -)-Isomer

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