PMID: 9160343Feb 1, 1997Paper

Long-lasting depression of soleus motoneurons excitability following repetitive magnetic stimuli of the spinal cord in multiple sclerosis patients

Multiple Sclerosis : Clinical and Laboratory Research
J F Nielsen, T Sinkjaer

Abstract

The effect of repetitive magnetic stimulation at the spinal level on the soleus H-reflex amplitude was evaluated in II MS patients with lower limb spasticity and in nine healthy subjects. In MS patients stimulation with a train of 16 stimuli at 25 Hz induced a decrease in amplitude to 61.2 +/- 25.7% of the unconditioned H-reflex amplitude at interstimulus interval (ISI) of 10-1000 ms (P < 0.01). The amount of decrease in H-reflex amplitude was highly dependent on the stimulation intensity and the placement of the coil, and to a lesser extent influenced by the stimulation frequency. No decrease in motor evoked potentials (MEPs) evoked by transcranial magnetic stimulation was seen following trains of 16 stimuli at mid-thoracic in contrast to the post-stimulation depression in H-reflex amplitude which could imply that mechanisms acting at presynaptic level were involved. In response to repetitive magnetic stimuli for 5 min, a long-lasting decrease in H-reflex amplitude to a level of about 70% of the pre-stimulation H-reflex amplitude occurred in MS patients (P < 0.01). A similar although not significant decrease was observed in healthy subjects. We propose that long-lasting depression of the soleus H-reflex amplitude after repetit...Continue Reading

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Citations

May 9, 2009·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Joachim PiatkowskiTjalf Ziemssen
Oct 30, 2009·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·F MoriD Centonze
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Oct 10, 2012·Pediatric Neurology·Véronique H FlamandCyril Schneider
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