Long-lasting effect of NMDA receptor antagonist memantine on ethanol-cue association and relapse

Journal of Neurochemistry
Valentina VengelieneRainer Spanagel

Abstract

It is well known that the glutamatergic system plays a crucial role in alcohol addiction and especially in relapse-like behaviour. However, results of clinical studies on compounds that influence the activity of the glutamatergic system have been disappointing so far. The aim of our study was to establish treatment conditions under which the N-methyl-d-aspartate receptor (NMDAR) antagonist memantine may produce more reliable treatment effect with respect to alcohol relapse-like behaviour. For this purpose, male Wistar rats were trained to associate several discrete stimuli with ethanol delivery. Thereafter, half of the animals received a brief memory reactivation session followed by two administrations of 20 mg/kg of memantine, while the other half received the same treatment without memory reactivation. Afterwards, a cue-induced ethanol-seeking behaviour test was performed followed by repeated extinction sessions and a reacquisition test. Our data show that administration of memantine reduced responding on the ethanol-associated lever in a cue-induced ethanol-seeking test. This reduction did not depend on whether or not a memory reactivation session was introduced prior to memantine administration. Following extinction, howeve...Continue Reading

References

Oct 31, 1996·European Journal of Pharmacology·S M HölterR Spanagel
Mar 24, 1998·Annual Review of Medicine·G Tsai, J T Coyle
Apr 22, 2004·Alcoholism, Clinical and Experimental Research·Pia Bäckström, Petri Hyytiä
Mar 3, 2007·The American Journal of Psychiatry·Evgeny M KrupitskyJohn H Krystal
Mar 24, 2007·Alcoholism, Clinical and Experimental Research·Suzette M EvansFatima Garawi
Aug 21, 2007·Biochemical Pharmacology·Justin T Gass, M Foster Olive
Mar 4, 2008·British Journal of Pharmacology·V VengelieneR Spanagel
Oct 24, 2008·Alcohol and Alcoholism : International Journal of the Medical Council on Alcoholism·Valentina VengelieneRainer Spanagel
Jul 27, 2010·Biological Psychiatry·Valentina VengelieneRainer Spanagel
Feb 19, 2013·Addiction Biology·Jérôme JeanblancMickaël Naassila
Sep 3, 2013·Psychopharmacology·Andrew HolmesJohn H Krystal
Nov 29, 2013·Addiction Biology·Rainer SpanagelEske M Derks
Aug 21, 2014·Addiction Biology·Stéphanie Alaux-CantinMickaël Naassila

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Citations

Aug 1, 2016·Psychopharmacology·Valentina VengelieneRainer Spanagel
Dec 28, 2016·Journal of Clinical Psychopharmacology·Fong ChangJohn H Krystal
Sep 22, 2016·Journal of Psychopharmacology·Christopher J Fitzpatrick, Jonathan D Morrow
Mar 8, 2018·PloS One·Mehdi BorjkhaniMahyar Janahmadi
Aug 18, 2018·Learning & Memory·Marc T J Exton-McGuinness, Amy L Milton
Aug 18, 2018·Frontiers in Computational Neuroscience·Mehdi BorjkhaniMahyar Janahmadi
May 1, 2021·International Journal of Molecular Sciences·Segev Barak, Koral Goltseker

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