Long-Lasting Effect of Transcranial Direct Current Stimulation in the Reversal of Hyperalgesia and Cytokine Alterations Induced by the Neuropathic Pain Model

Brain Stimulation
Stefania Giotti CioatoIraci L S Torres

Abstract

Neuropathic pain (NP) is caused by an insult or dysfunction in the peripheral or central nervous system (CNS), the main symptoms being mechanical allodynia and hyperalgesia. NP often shows insufficient response to classic analgesics and its management remains a challenge. Transcranial direct current stimulation (tDCS) is a non-invasive method of cerebral stimulation and represents a promising resource for pain management. We investigated the effects of tDCS on the nociceptive response and on IL-1β, IL-10, and TNF-α levels in CNS structures of rats with NP. After induction of NP by chronic constriction injury (CCI) of the sciatic nerve, the rats received 20 min of bicephalic tDCS for 8 days. Hyperalgesia was assessed by the hot plate and von Frey tests and evaluated at baseline, 7 days, and 14 days after CCI surgery, and also immediately, 24 hours, and 7 days following tDCS treatment. The levels of IL-1β, IL-10 and TNF-α in the cortex, spinal cord, and brainstem were determined by ELISA at 48 hours and 7 days post-tDCS. The CCI model provoked thermal and mechanical hyperalgesia until at least 30 days post-CCI; however, bicephalic tDCS relieved the nociceptive behavior for up to 7 days after treatment completion. Bicephalic tDCS ...Continue Reading

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Citations

Jan 4, 2017·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ellen A NunesIraci L S Torres
Jun 2, 2017·Phytotherapy Research : PTR·Rebeca Vargas Antunes SchunckMirna Bainy Leal
Sep 4, 2018·Expert Opinion on Therapeutic Patents·Marluce Pereira Damasceno LimaFernanda Regina de Castro Almeida
Oct 4, 2018·Journal of Oral Rehabilitation·Vanessa L ScarabelotIraci L S Torres
Nov 6, 2018·CNS & Neurological Disorders Drug Targets·Antonio IbarraTamara D Frydman
Sep 19, 2017·Molecular Neurobiology·Damien P Kuffler
Jul 1, 2017·Frontiers in Behavioral Neuroscience·Hui-Zhong WenHuai-Zhen Ruan
May 14, 2020·BMC Neuroscience·Ke-Ying ZhangGui-Rong Ding
Nov 25, 2016·Frontiers in Human Neuroscience·Anthony T O'BrienAntoni Valero-Cabré
Aug 17, 2020·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Liciane Fernandes MedeirosIraci L S Torres
Jul 18, 2018·Current Behavioral Neuroscience Reports·Carlos A Sánchez-LeónJavier Márquez-Ruiz
Aug 28, 2020·Expert Review of Medical Devices·Kevin Pacheco-BarriosFelipe Fregni
Jun 24, 2017·Menopause : the Journal of the North American Menopause Society·Mônia Steigleder BianchiMaria Celeste Osório Wender
Nov 9, 2020·Purinergic Signalling·Stefania Giotti CioatoIraci L S Torres
Dec 8, 2020·Frontiers in Human Neuroscience·Giuseppina PilloniLeigh E Charvet

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