PMID: 6162525Mar 2, 1981Paper

Long lasting effects of intrauterine growth retardation of 5-HT metabolism in the brain of developing rats

Brain Research
C ChanezA Minkowski

Abstract

Intrauterine growth retardation (IUGR) was achieved by ligating the artery and vein supplying one uterine horn in pregnant rats on the 5th day before delivery. At birth, the weight of the whole body and of the forebrain (but not that of the brain stem of about half of the offspring) were significantly lower than those of normal controls. This deficit persisted for at least the first 3 postnatal weeks. During the immediate period following birth, the concentrations of norepinephrine, dopamine, serotonin and 5-hydroxyindoleacetic acid (5-HIAA) were significantly higher in IUGR rats than in controls. Increased levels of serotonin and 5-HIAA were still observed in the forebrain and brain stem of 15-day-old IUGR rats and were associated with parallel increases in brain and serum free tryptophan levels. These results indicate that a transient insult in the fetal life could result in long-lasting alterations in 5-HT metabolism in CNS of developing rats.

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Citations

Mar 1, 1993·Metabolic Brain Disease·C ChanezJ F Giguere
Jul 27, 2007·Reviews in Endocrine & Metabolic Disorders·Thomas J McDonaldPeter W Nathanielsz
May 1, 1989·Brain Research. Developmental Brain Research·A RepresaY Ben-Ari
Dec 1, 1994·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·G G ManjarrezJ Hernández
Apr 6, 2004·Brain Research. Brain Research Reviews·Patricia Boksa
Nov 24, 1999·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·G UzümZ Ziylan
Mar 10, 1998·Pediatric Neurology·G ManjarrezJ Hernández-R
Jun 12, 2016·Physiology & Behavior·Damien S HunterKathryn L Gatford
Oct 26, 2016·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·M Vázquez-GómezA González-Bulnes
Oct 24, 1998·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·A HayashiN Okado
Aug 1, 1996·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·G G ManjarrezJ Hernández
Aug 25, 2001·Nutrition Reviews·J Hernández-Rodriguez, G Manjarrez-Gutiérrez

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