Long-lasting increase in axonal excitability after epidurally applied DC

Journal of Neurophysiology
E JankowskaIngela Hammar

Abstract

Effects of direct current (DC) on nerve fibers have primarily been investigated during or just after DC application. However, locally applied cathodal DC was recently demonstrated to increase the excitability of intraspinal preterminal axonal branches for >1 h. The aim of this study was therefore to investigate whether DC evokes a similarly long-lasting increase in the excitability of myelinated axons within the dorsal columns. The excitability of dorsal column fibers stimulated epidurally was monitored by recording compound action potentials in peripheral nerves in acute experiments in deeply anesthetized rats. The results show that 1) cathodal polarization (0.8-1.0 µA) results in a severalfold increase in the number of epidurally activated fibers and 2) the increase in the excitability appears within seconds, 3) lasts for >1 h, and 4) is activity independent, as it does not require fiber stimulation during the polarization. These features demonstrate an unexplored form of plasticity of myelinated fibers and indicate the conditions under which it develops. They also suggest that therapeutic effects of epidural stimulation may be significantly enhanced if it is combined with DC polarization. In particular, by using DC to increa...Continue Reading

References

Feb 3, 1999·Annals of the New York Academy of Sciences·M R DimitrijevicM M Pinter
Dec 18, 2003·Supplements to Clinical Neurophysiology·Michael A NitscheWalter Paulus
Nov 19, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Ramal M S WeragodaEdgar T Walters
Mar 5, 2005·The Journal of Physiology·Hugh BostockDavid Burke
Apr 25, 2006·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Hiroyuki Nodera, Ryuji Kaji
Dec 3, 2008·The Journal of Physiology·David BurkeMatthew C Kiernan
Jan 29, 2010·Journal of Neurophysiology·Katia Monte-SilvaMichael A Nitsche
Jul 1, 2008·Brain Stimulation·Michael A NitscheAlvaro Pascual-Leone
Mar 17, 2011·Medical & Biological Engineering & Computing·Gabriel R Hernández-LabradoJorge E Collazos-Castro
Apr 30, 2011·Physiological Reviews·Dominique DebanneGisèle Alcaraz
Jul 1, 2010·Neuromodulation : Journal of the International Neuromodulation Society·Cristy M SchadeLisa M Johanek
Jan 1, 2002·Neuromodulation : Journal of the International Neuromodulation Society·Jan Holsheimer
Jan 31, 2012·Neuron·Maarten H P Kole, Greg J Stuart
Jan 10, 2013·Current Pain and Headache Reports·Chitra RamasubbuKayode Williams
Mar 20, 2013·The Journal of Physiology·Francesco BolzoniElzbieta Jankowska
Aug 3, 2014·The Journal of Physiology·M Bączyk, E Jankowska
Apr 4, 2015·Neuromodulation : Journal of the International Neuromodulation Society·Jan Holsheimer, Jan R Buitenweg
Aug 28, 2015·Current Opinion in Neurobiology·Rylan S Larsen, P Jesper Sjöström
Mar 19, 2016·The European Journal of Neuroscience·Elzbieta JankowskaIngela Hammar
Sep 14, 2016·Journal of Neural Engineering·B J HolinskiV K Mushahwar
Oct 27, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mark P JacksonMarom Bikson
Nov 21, 2016·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Jean-Pascal LefaucheurWalter Paulus
Feb 18, 2017·Dose-response : a Publication of International Hormesis Society·James GiordanoEdward Calabrese

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Citations

Nov 5, 2019·The European Journal of Neuroscience·Marcin BączykPiotr Krutki
Oct 13, 2020·Physiological Measurement·James HopeAndrew McDaid
Sep 16, 2021·Journal of Neurophysiology·Elzbieta Jankowska, Ingela Hammar

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