Long-lasting modulation of synaptic plasticity in rat hippocampus after early-life complex febrile seizures

The European Journal of Neuroscience
R G E NotenboomP N E de Graan

Abstract

A small fraction of children with febrile seizures appears to develop cognitive impairments. Recent studies in a rat model of hyperthermia-induced febrile seizures indicate that prolonged febrile seizures early in life have long-lasting effects on the hippocampus and induce cognitive deficits. However, data on network plasticity and the nature of cognitive deficits are conflicting. We examined three specific measures of hippocampal plasticity in adult rats with a prior history of experimental febrile seizures: (i) activity-dependent synaptic plasticity (long-term potentiation and depression) by electrophysiological recordings of Schaffer collateral/commissural-evoked field excitatory synaptic potentials in CA1 of acute hippocampal slices; (ii) Morris water maze spatial learning and memory; and (iii) hippocampal mossy fiber plasticity by Timm histochemistry and quantification of terminal sprouting in CA3 and the dentate gyrus. We found enhanced hippocampal CA1 long-term potentiation and reduced long-term depression but normal spatial learning and memory in adult rats that were subjected to experimental febrile seizures on postnatal day 10. Furthermore, rats with experimental febrile seizures showed modest but significant sprouti...Continue Reading

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Citations

Jan 18, 2014·International Journal of Developmental Neuroscience : the Official Journal of the International Society for Developmental Neuroscience·Ebrahim RajabAmer Kamal
Mar 8, 2014·Neurotherapeutics : the Journal of the American Society for Experimental NeuroTherapeutics·Katelin P PattersonShlomo Shinnar
Dec 21, 2010·Seizure : the Journal of the British Epilepsy Association·Kjell HeuserErik Taubøll
Aug 27, 2016·Neuroscience Bulletin·Bo Feng, Zhong Chen
Nov 5, 2014·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Ryuta Koyama
Sep 25, 2017·The International Journal of Neuroscience·Xiaoqian ZhangWeiyu Teng
Jan 26, 2021·Cellular and Molecular Neurobiology·M CrespoM Martín
Aug 8, 2021·International Journal of Molecular Sciences·Tatyana Y PostnikovaAleksey V Zaitsev

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