Long lasting pain hypersensitivity following ligation of the tendon of the masseter muscle in rats: a model of myogenic orofacial pain.

Molecular Pain
Wei GuoKe Ren

Abstract

A major subgroup of patients with temporomandibular joint (TMJ) disorders have masticatory muscle hypersensitivity. To study myofacial temporomandibular pain, a number of preclinical models have been developed to induce myogenic pain of the masseter muscle, one of the four muscles involved in mastication. The currently used models, however, generate pain that decreases over time and only lasts from hours to weeks and hence are not suitable for studying chronicity of the myogenic pain in TMJ disorders. Here we report a model of constant myogenic orofacial pain that lasts for months. The model involves unilateral ligation of the tendon of the anterior superficial part of the rat masseter muscle (TASM). The ligation of the TASM was achieved with two chromic gut (4.0) ligatures via an intraoral approach. Nocifensive behavior of the rat was assessed by probing the skin site above the TASM with a series of von Frey filaments. The response frequencies were determined and an EF50 value, defined as the von Frey filament force that produces a 50% response frequency, was derived and used as a measure of mechanical sensitivity. Following TASM ligation, the EF50 of the injured side was significantly reduced and maintained throughout the 8-w...Continue Reading

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Citations

Feb 12, 2011·Science·Joshua B Plotkin
Jan 25, 2014·Life Sciences·Marcelo R BergaminiCintia H C Saraceni
Nov 1, 2012·Pain Medicine : the Official Journal of the American Academy of Pain Medicine·Shuxing WangJianren Mao
May 7, 2013·The Journal of Pain : Official Journal of the American Pain Society·Ye CaoBarry J Sessle
Oct 9, 2012·Peptides·Richard J Bodnar
Nov 10, 2012·Brain and Behavior·Agnieszka Krzyzanowska, Carlos Avendaño
Feb 11, 2015·Physiology & Behavior·Ya-Juan ZhaoYong-Jin Chen
Sep 18, 2018·Expert Opinion on Drug Discovery·Heitor G Araújo-FilhoJullyana S S Quintans
Jan 19, 2013·Acupuncture in Medicine : Journal of the British Medical Acupuncture Society·Qiang-Min HuangLi Tang
Sep 30, 2020·International Journal of Oral Science·Jun LiDi Chen
Nov 22, 2018·Frontiers in Integrative Neuroscience·Wei GuoKe Ren
Jun 3, 2021·International Journal of Molecular Sciences·Yi YeJennifer Gibbs

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BETA
protein assay

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GraphPad
SPOT
Adobe Photoshop
Prism

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