Long-lasting production of new T and B cells and T-cell repertoire diversity in patients with primary immunodeficiency who had undergone stem cell transplantation: a single-centre experience

Journal of Immunology Research
Monica ValottiLuisa Imberti

Abstract

Levels of Kappa-deleting recombination excision circles (KRECs), T-cell receptor excision circles (TRECs), and T-cell repertoire diversity were evaluated in 1038 samples of 124 children with primary immunodeficiency, of whom 102 (54 with severe combined immunodeficiency and 48 with other types of immunodeficiency) underwent hematopoietic stem cell transplantation. Twenty-two not transplanted patients with primary immunodeficiency were used as controls. Only data of patients from whom at least five samples were sent to the clinical laboratory for routine monitoring of lymphocyte reconstitutions were included in the analysis. The mean time of the follow-up was 8 years. The long-lasting posttransplantation kinetics of KREC and TREC production occurred similarly in patients with severe combined immunodeficiency and with other types of immunodeficiency and, in both groups, the T-cell reconstitution was more efficient than in nontransplanted children. Although thymic output decreased in older transplanted patients, the degree of T-cell repertoire diversity, after an initial increase, remained stable during the observation period. However, the presence of graft-versus-host disease and ablative conditioning seemed to play a role in the...Continue Reading

References

Feb 18, 1999·The New England Journal of Medicine·R H BuckleyF E Ward
Feb 21, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Marcella SarzottiRebecca H Buckley
Sep 11, 2007·The Journal of Allergy and Clinical Immunology·Evelina MazzolariLuigi D Notarangelo
Oct 24, 2007·The Journal of Allergy and Clinical Immunology·Raif S GehaUNKNOWN International Union of Immunological Societies Primary Immunodeficiency Diseases Classification Committee
May 13, 2009·Blood·Marcella Sarzotti-KelsoeRebecca H Buckley
Apr 8, 2010·The Journal of Allergy and Clinical Immunology·Rebecca H Buckley
May 11, 2010·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Alessandra SottiniLuisa Imberti
May 21, 2010·Nature Immunology·Alain FischerMarina Cavazzana-Calvo
Nov 9, 2010·The Journal of Immunology : Official Journal of the American Association of Immunologists·Federico SeranaLuisa Imberti
Nov 19, 2011·Pediatric Transplantation·Laura DinardoKathleen E Sullivan
Feb 7, 2012·Blood·Juliana F FernandesUNKNOWN Eurocord and Inborn Errors Working Party of European Group for Blood and Marrow Transplantation
Nov 22, 2012·British Journal of Haematology·Marina Cavazzana-CalvoAlain Fischer
Mar 8, 2013·The Journal of Allergy and Clinical Immunology·Elie HaddadRebecca H Buckley
Jun 3, 2014·The Journal of Allergy and Clinical Immunology·Stephan BorteYenan T Bryceson

❮ Previous
Next ❯

Citations

Nov 23, 2016·Journal of Clinical Immunology·Michela BarbaroLennart Hammarström

❮ Previous
Next ❯

Methods Mentioned

BETA
PCR

Related Concepts

Related Feeds

Allogenic & Autologous Therapies

Allogenic therapies are generated in large batches from unrelated donor tissues such as bone marrow. In contrast, autologous therapies are manufactures as a single lot from the patient being treated. Here is the latest research on allogenic and autologous therapies.

Blood And Marrow Transplantation

The use of hematopoietic stem cell transplantation or blood and marrow transplantation (bmt) is on the increase worldwide. BMT is used to replace damaged or destroyed bone marrow with healthy bone marrow stem cells. Here is the latest research on bone and marrow transplantation.