Long-lasting sensitization induced by repeated risperidone treatment in adolescent Sprague-Dawley rats: a possible D2 receptor mediated phenomenon?

Psychopharmacology
Jing QiaoMing Li

Abstract

Risperidone use in children and adolescents for the treatment of various neuropsychiatric disorders (e.g., schizophrenia, autism, disruptive behavior, etc.) has increased substantially in recent decades. However, its long-term effect on the brain and behavioral functions is not well understood. The present study investigated how a short-term risperidone treatment in adolescence impacts antipsychotic response in adulthood in the conditioned avoidance response and phencyclidine (PCP)-induced hyperlocomotion tests. Male adolescent Sprague-Dawley rats (postnatal days [P] 40-44 or 43-48) were first treated with risperidone (0.3, 0.5, or 1.0 mg/kg, subcutaneously (sc)) and tested in the conditioned avoidance or PCP (3.2 mg/kg, sc)-induced hyperlocomotion model daily for five consecutive days. After they became adults (~P 76-80), they were challenged with risperidone (0.3 mg/kg, sc) to assess their sensitivity to risperidone reexposure. A quinpirole (a D2/3 receptor agonist, 1.0 mg/kg, sc)-induced hyperlocomotion test was later conducted to assess the risperidone-induced functional changes in D2 receptor. In the risperidone challenge test in adulthood, adult rats previously treated with risperidone in adolescence made significantly fe...Continue Reading

References

Aug 1, 1987·Neuropharmacology·W KollerJ Gordon
Dec 2, 1998·Behavioural Pharmacology·M A AguilarJ Miñarro
Oct 30, 2001·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·M L WadenbergS Kapur
Feb 28, 2003·The Journal of Pharmacology and Experimental Therapeutics·Shitij KapurJose N Nobrega
Nov 1, 2003·The Journal of Pharmacology and Experimental Therapeutics·Kerry E Culm, Ronald P Hammer
May 24, 2005·Journal of the American Academy of Child and Adolescent Psychiatry·Nick C PatelPeter S Jensen
Jun 2, 2006·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Ming LiShitij Kapur
Jun 7, 2006·Archives of General Psychiatry·Mark OlfsonGonzalo Laje
Dec 19, 2006·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Taylor Moran-GatesFrank I Tarazi
Jul 5, 2007·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·John M DavisIra D Glick
May 3, 2008·Psychiatric Services : a Journal of the American Psychiatric Association·Luuk J KalverdijkLolkje T W de Jong-van den Berg
Oct 11, 2008·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Yong Kee ChoiFrank I Tarazi
Oct 31, 2009·European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology·Yong Kee ChoiFrank I Tarazi
Feb 20, 2010·Pharmacology, Biochemistry, and Behavior·Tao SunMing Li
Feb 27, 2010·European Journal of Pharmacology·Tao SunMing Li
May 24, 2011·Neuroscience and Biobehavioral Reviews·Heather C Brenhouse, Susan L Andersen
Jun 11, 2011·The Journal of Clinical Psychiatry·Christoph U CorrellJohn S March
Jul 21, 2011·Archives of Disease in Childhood. Education and Practice Edition·Noor B Almandil, Ian C K Wong
Jun 1, 2012·The International Journal of Neuropsychopharmacology·María Jesús Luque-RojasEduardo Blanco Calvo
Nov 8, 2012·Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology·Jing QiaoMing Li
Jan 29, 2013·The International Journal of Neuropsychopharmacology·Monika VinishDouglas O Frost

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Citations

Apr 17, 2017·Behavioural Brain Research·Xiaojing DingMing Li
Jul 15, 2016·Journal of Psychopharmacology·Aung Aung Kywe MoeDarryl W Eyles

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