Long-latency interhemispheric interactions between motor-related areas and the primary motor cortex: a dual site TMS study

Scientific Reports
Francesca FioriAlessio Avenanti

Abstract

The primary motor cortex (M1) is highly influenced by premotor/motor areas both within and across hemispheres. Dual site transcranial magnetic stimulation (dsTMS) has revealed interhemispheric interactions mainly at early latencies. Here, we used dsTMS to systematically investigate long-latency causal interactions between right-hemisphere motor areas and the left M1 (lM1). We stimulated lM1 using a suprathreshold test stimulus (TS) to elicit motor-evoked potentials (MEPs) in the right hand. Either a suprathreshold or a subthreshold conditioning stimulus (CS) was applied over the right M1 (rM1), the right ventral premotor cortex (rPMv), the right dorsal premotor cortex (rPMd) or the supplementary motor area (SMA) prior to the TS at various CS-TS inter-stimulus intervals (ISIs: 40-150 ms). The CS strongly affected lM1 excitability depending on ISI, CS site and intensity. Inhibitory effects were observed independently of CS intensity when conditioning PMv, rM1 and SMA at a 40-ms ISI, with larger effects after PMv conditioning. Inhibition was observed with suprathreshold PMv and rM1 conditioning at a 150-ms ISI, while site-specific, intensity-dependent facilitation was detected at an 80-ms ISI. Thus, long-latency interhemispheric i...Continue Reading

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Citations

Aug 29, 2018·Brain Connectivity·Karita Suvi-Tuuli SaloRisto J Ilmoniemi
Jan 18, 2019·Human Brain Mapping·Quentin WelniarzEmmanuel Roze
Nov 28, 2019·Journal of Neurophysiology·Sandrine L CôtéNuma Dancause
Mar 21, 2020·Journal of Motor Behavior·Sagarika BhattacharjeeShahid Bashir
Mar 5, 2020·Journal of Neurophysiology·Boris TouvykineNuma Dancause
Mar 23, 2019·Frontiers in Neurology·Christopher FrickeJoseph Classen
Oct 13, 2020·Cortex; a Journal Devoted to the Study of the Nervous System and Behavior·Sara BorgomaneriSimone Battaglia
Jul 25, 2021·Behavioural Brain Research·Giacomo GuidaliNadia Bolognini
Jul 13, 2021·Neuromodulation : Journal of the International Neuromodulation Society·Shreya ParchureRoy H Hamilton
Sep 2, 2021·The European Journal of Neuroscience·Brittany K RurakAnn-Maree Vallence

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BETA
SMA

Software Mentioned

SofTaxic
MRIcron

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