Long-latency reductions in gamma power predict hemodynamic changes that underlie the negative BOLD signal

The Journal of Neuroscience : the Official Journal of the Society for Neuroscience
Luke BoormanJason Berwick

Abstract

Studies that use prolonged periods of sensory stimulation report associations between regional reductions in neural activity and negative blood oxygenation level-dependent (BOLD) signaling. However, the neural generators of the negative BOLD response remain to be characterized. Here, we use single-impulse electrical stimulation of the whisker pad in the anesthetized rat to identify components of the neural response that are related to "negative" hemodynamic changes in the brain. Laminar multiunit activity and local field potential recordings of neural activity were performed concurrently with two-dimensional optical imaging spectroscopy measuring hemodynamic changes. Repeated measurements over multiple stimulation trials revealed significant variations in neural responses across session and animal datasets. Within this variation, we found robust long-latency decreases (300 and 2000 ms after stimulus presentation) in gamma-band power (30-80 Hz) in the middle-superficial cortical layers in regions surrounding the activated whisker barrel cortex. This reduction in gamma frequency activity was associated with corresponding decreases in the hemodynamic responses that drive the negative BOLD signal. These findings suggest a close rel...Continue Reading

Citations

Sep 21, 2016·NeuroImage·Michael Bruyns-HaylettYing Zheng
Dec 16, 2016·Proceedings of the National Academy of Sciences of the United States of America·Ying MaElizabeth M C Hillman
Jul 17, 2020·Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism·Hyun-Kyoung LimMinah Suh
Nov 17, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Clare HowarthCatherine N Hall

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