Long ligands reinforce biological adhesion under shear flow
Abstract
In this work, computer modeling has been used to show that longer ligands allow biological cells (e.g., blood platelets) to withstand stronger flows after their adhesion to solid walls. A mechanistic model of polymer-mediated ligand-receptor adhesion between a microparticle (cell) and a flat wall has been developed. The theoretical threshold between adherent and non-adherent regimes has been derived analytically and confirmed by simulations. These results lead to a deeper understanding of numerous biophysical processes, e.g., arterial thrombosis, and to the design of new biomimetic colloid-polymer systems.
References
The effect of shear rate on platelet interaction with subendothelium exposed to citrated human blood
Blood flow velocity effects and role of activation delay time on growth and form of platelet thrombi
GPIbα-vWF rolling under shear stress shows differences between type 2B and 2M von Willebrand disease
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