Long-lived animals with negligible senescence: clues for ageing research

Biochemical Society Transactions
Peter Stenvinkel, Paul G Shiels

Abstract

Among several theories to explain the complicated process of human ageing, the mitochondrial oxidative stress hypothesis has received recent attention. Considering that lifespan and ageing rates vary considerably across taxa, a better understanding of factors that lead to negligible or extremely rapid senescence in mammals may generate novel approaches to target human ageing. Several species, such as naked mole rats, ocean quahog, rockfish and Greenland shark, have been identified that exhibit negligible senescence and superior resistance to age-related diseases. Considering that the available literature suggests that their outstanding stress resistance is linked to maintenance of protein homeostasis and robust mitochondrial functions, treatments that target protein modification and upregulation of matrix antioxidants may have implications for extending human health span.

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Citations

Oct 23, 2019·Journal of Internal Medicine·P StenvinkelB Natterson-Horowitz
May 20, 2021·Antioxidants & Redox Signaling·Thomas EbertPaul G Shiels
Jun 18, 2021·Scientific Reports·Hannah CravenPaul G Shiels
Jul 3, 2021·Frontiers in Cell and Developmental Biology·Ysabel Milton GiraldoJames F A Traniello
Jul 29, 2021·The Biochemical Journal·Paul G ShielsPeter Stenvinkel
Aug 10, 2021·Journal of Clinical and Translational Science·Peter StenvinkelPaul G Shiels
Aug 27, 2021·Oxidative Medicine and Cellular Longevity·Elisa Gorostieta-SalasSusana Castro-Obregón
Sep 17, 2021·Frontiers in Integrative Neuroscience·Daniela S RiveraNibaldo C Inestrosa

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