Long-lived ionic nano-domains can modulate the stiffness of soft interfaces

Nanoscale
William TrewbyKislon Voïtchovsky

Abstract

Metal ions underpin countless processes at bio-interfaces, including maintaining electroneutrality, modifying mechanical properties and driving bioenergetic activity. These processes are typically described by ions behaving as independently diffusing point charges. Here we show that Na+ and K+ ions instead spontaneously form correlated nanoscale networks that evolve over seconds at the interface with an anionic bilayer in solution. Combining single-ion level atomic force microscopy and molecular dynamic simulations we investigate the configuration and dynamics of Na+, K+, and Rb+ at the lipid surface. We identify two distinct ionic states: the well-known direct electrostatic interaction with lipid headgroups and a water-mediated interaction that can drive the formation of remarkably long-lived ionic networks which evolve over many seconds. We show that this second state induces ionic network formation via correlative ion-ion interactions that generate an effective energy well of -0.4kBT/ion. These networks locally reduce the stiffness of the membrane, providing a spontaneous mechanism for tuning its mechanical properties with nanoscale precision. The ubiquity of water-mediated interactions suggest that our results have far-reac...Continue Reading

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Citations

Feb 23, 2020·Nanoscale·William FosterKislon Voϊtchovsky
Aug 8, 2020·Small·Stefano ChiodiniPilar Cea
Jan 16, 2021·Nanoscale·Victor G GisbertRicardo Garcia
Feb 17, 2021·Journal of Colloid and Interface Science·Aaron ElbourneAndrew J Christofferson
Jul 3, 2021·Membranes·Vanesa Viviana Galassi, Natalia Wilke
Apr 2, 2020·The Journal of Physical Chemistry Letters·Alexandre M EmelyanenkoLudmila B Boinovich
Jul 21, 2020·The Journal of Physical Chemistry Letters·Evelyne DeplazesAlvaro Garcia

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Methods Mentioned

BETA
protein folding
atomic force microscopy
electrophoresis
AFM
using

Software Mentioned

CHARMM36
NAMD

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