Long-lived protective immunity to Listeria is conferred by immunization with particulate or soluble listerial antigen preparations coadministered with IL-12

Cellular Immunology
M A MillerH K Ziegler

Abstract

The ability of IL-12 to promote the development of Th1-type immune responses, and thus promote cellular immunity, has been well documented. In a previous report, we showed that coadministration of IL-12 with heat-killed Listeria monocytogenes elicited intense antigen-specific T cell responses that conferred protective listerial immunity. Herein, we have extended those studies by demonstrating that multiple injections of heat-killed L. monocytogenes and IL-12 elicit memory responses that confer long-lived (> or = 3 months) protective immunity and that immunity can be transferred adoptively with cells from immunized mice injected into naive mice. These studies have also demonstrated that the powerful adjuvanticity of IL-12 is observed with soluble as well as particulate immunogens and is operative in mouse strains that have different MHC haplotypes. These findings suggest that IL-12 may be a useful adjuvant component of vaccines for a wide variety of pathogens in animal and human systems.

References

Aug 1, 1992·Cellular Immunology·M K GatelyR Chizzonite
Nov 1, 1989·The Journal of Experimental Medicine·T Goodman, L Lefrancois
Mar 1, 1987·Proceedings of the National Academy of Sciences of the United States of America·O LeoJ A Bluestone
Feb 14, 1985·The New England Journal of Medicine·M Barza
Jun 1, 1966·Bacteriological Reviews·M L Gray, A H Killinger
May 1, 1969·The Journal of Experimental Medicine·G B Mackaness, W C Hill
Apr 1, 1995·British Journal of Cancer·R E BanksP J Selby
Jan 1, 1995·European Journal of Immunology·M A CassatellaG Trinchieri
May 1, 1994·Infection and Immunity·I A KhanL H Kasper
Aug 15, 1994·Annals of the New York Academy of Sciences·H K ZieglerK M Pearce
May 1, 1993·The Journal of Experimental Medicine·F P HeinzelM K Gately
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·R T GazzinelliA Sher
Sep 1, 1993·The Journal of Experimental Medicine·M J Skeen, H K Ziegler
Aug 1, 1993·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·R L JuradoD S Stephens
Oct 31, 1996·Annals of the New York Academy of Sciences·A SherT Wynn
Feb 1, 1997·Infection and Immunity·E B LindbladP Andersen
Jan 1, 1997·Current Opinion in Hematology·G Trinchieri
Jan 1, 1997·International Reviews of Immunology·K KumagaiH Rikiishi
Jun 1, 1964·The Journal of Infectious Diseases·A S ARMSTRONG, C P SWORD

❮ Previous
Next ❯

Citations

Dec 19, 2000·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·B Spellberg, J E Edwards
Nov 5, 2002·Annual Review of Immunology·Phillip Wong, Eric G Pamer
Jan 17, 2003·Proceedings of the National Academy of Sciences of the United States of America·Steven R LeongJuha Punnonen
Feb 24, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Mischo KursarHans-Willi Mittrücker

❮ Previous
Next ❯

Related Concepts

Related Feeds

Avian Influenza: Innate Immune Adjuvant (ASM)

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.

Avian Influenza: Innate Immune Adjuvant

Adjuvants systems that are added to vaccines against avian influenza have be explored to enhance the innate immune system response against the virus. Here is the latest research on avian influenza and the innate immune adjuvant.