Long-lived worms and aging

Redox Report : Communications in Free Radical Research
Yuan Luo

Abstract

Several investigators have generated long-lived nematode worms (Caenorhabditis elegans) in the past decade by mutation of genes in the organism in order to study the genetics of aging and longevity. Dozens of longevity assurance genes (LAG) that dramatically increase the longevity of this organism have been identified. All long-lived mutants of C. elegans are also resistant to environmental stress, such as high temperature, reactive oxygen species (ROS), and ultraviolet irradiation. Double mutations of some LAGs further extended life span up to 400%, providing more insight into cellular mechanisms that put limits on the life span of organisms. With the availability of the LAG mutants and the combined DNA microarray and RNAi technology, the understanding of actual biochemical processes that determine life span is within reach: the downstream signal transduction pathway may regulate life span by up-regulating pro-longevity genes such as those that encode antioxidant enzymes and/or stress-response proteins, and down-regulating specific life-shortening genes. Furthermore, longevity could be modified through chemical manipulation. Results from these studies further support the free radical theory of aging, suggest that the molecular...Continue Reading

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Citations

Dec 3, 2005·Evidence-based Complementary and Alternative Medicine : ECAM·Pierre S HaddadMichel Boivin
Jan 2, 2008·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Zhiming CaoYuan Luo
Nov 20, 2012·Journal of Cellular Biochemistry·Jing LiuJing Ai
Jun 5, 2007·Experimental Gerontology·Peter RuzanovSteven M Jones
Jun 11, 2019·Oxidative Medicine and Cellular Longevity·Ricardo Basílio de Oliveira CalandRiva de Paula Oliveira
Sep 23, 2011·Aging·Katherine I ZhouFrank J Slack

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