Long non-coding RNA 00607 as a tumor suppressor by modulating NF-κB p65/p53 signaling axis in hepatocellular carcinoma

Carcinogenesis
Qi-Man SunJia Fan

Abstract

Accumulating evidence suggests that long non-coding RNA (lncRNA) plays important roles in some malignant tumors. However, the mechanism underlying how lncRNA regulates hepatocellular carcinoma (HCC) process remains largely unknown. In this study, we explored the potential role of lncRNA 00607 as a novel tumor suppressor in HCC. In this study, we examined the regulation of lncRNA 00607 by the important inflammatory cytokine tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). We also determined the expression of LINC000607 in 159 HCC tumors and paired adjacent tissues. Effects of LINC000607 in HCC proliferation and apoptosis were examined in vitro in HCC cell lines and in vivo tumor xenografts. Furthermore, we also examine underlying mechanism by which lncRNA 00607 regulates NF-κB p65 and how LIN00607 exerts its tumor suppressor role in HCC. We found that lncRNA 00607 expression level is lower in HCC tumors compared with matched normal liver tissue, and its low expression predicts worse prognosis in HCC. Functionally, lncRNA 00607 overexpression leads to decreased HCC cell proliferation in vitro and in vivo, enhanced apoptosis and chemotherapeutic drug sensitivity. Mechanistically, lncRNA 00607 inhibits the p65 transcriptio...Continue Reading

References

Apr 17, 1999·Molecular and Cellular Biology·G A Webster, N D Perkins
Oct 4, 2006·Alimentary Pharmacology & Therapeutics·C EvansD Kumar
Jun 16, 2007·The Journal of Biological Chemistry·Yunli ZhouAnne Klibanski
May 3, 2008·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Mark B MeadsWilliam S Dalton
Jul 3, 2009·Genes & Development·Jeremy E WiluszDavid L Spector
May 14, 2010·Cold Spring Harbor Perspectives in Biology·David Lane, Arnold Levine
Jun 16, 2010·Current Drug Targets·Jodi E Goldberg, Kathryn L Schwertfeger
Jul 3, 2010·Cold Spring Harbor Perspectives in Biology·Andrei V Gudkov, Elena A Komarova
Jun 30, 2011·AIDS Patient Care and STDs·Lisa B Hightow-WeidmanUNKNOWN YMSM of Color SPNS Initiative Study Group
Oct 17, 2012·CA: a Cancer Journal for Clinicians·Mary Maluccio, Anne Covey
Mar 19, 2013·Cell·Pedro J Batista, Howard Y Chang
Jan 1, 2011·Journal of Hospice and Palliative Nursing : JHPN : the Official Journal of the Hospice and Palliative Nurses Association·Gail M KeenanHan Yan
Oct 12, 2013·Clinical & Experimental Ophthalmology·Soo Khai NgJamie E Craig
Jan 28, 2014·Nature Structural & Molecular Biology·Ezgi HacisuleymanJohn L Rinn
Sep 13, 2014·Science·John Rinn, Mitchell Guttman
Dec 4, 2014·Nature·Lucas Laursen
Aug 19, 2015·Molecular and Cellular Endocrinology·Paweena ChunharojrithAnne Klibanski
Nov 26, 2015·Current Pharmaceutical Design·Morteza Ghandadi, Amirhossein Sahebkar
Jan 9, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Esra BozgeyikMehri Igci
Jan 20, 2016·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Menglin CongZhenzhong Li
Feb 20, 2016·PloS One·Rafet Al-TobaseiMohamed Salem
Mar 24, 2016·Genome Génome / Conseil National De Recherches Canada·Mohammad Reza BakhtiarizadehSeyed Alireza Salami
Mar 25, 2016·Nature·Eleonora LeucciJean-Christophe Marine
Apr 14, 2016·Cancer Cell·Adam M Schmitt, Howard Y Chang

❮ Previous
Next ❯

Citations

May 18, 2019·Journal of Experimental & Clinical Cancer Research : CR·Haoming MaiDeke Jiang
Apr 24, 2020·Cellular and Molecular Life Sciences : CMLS·Giovanna CarràAlessandro Morotti
Oct 31, 2020·Frontiers in Cell and Developmental Biology·Qiang GuoGang Xu
Jan 1, 2020·RNA Biology·Yan HuangXiangting Wang
Jan 29, 2021·World Journal of Gastroenterology : WJG·Guang-Lin LeiPeng-Hui Yang
Mar 24, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Soudeh Ghafouri-FardMohammad Taheri
May 11, 2021·Frontiers in Oncology·Soudeh Ghafouri-FardMohammad Taheri

❮ Previous
Next ❯

Related Concepts

Related Feeds

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.