Long non-coding RNA ABHD11-AS1 boosts gastric cancer development by regulating miR-361-3p/PDPK1 signalling.

Journal of Biochemistry
hairong xinjie cao

Abstract

Gastric cancer (GC) is one of the most common cancers in gastrointestinal malignant tumours. Long non-coding RNAs were widely reported to play a significant role in the regulation of occurrence or development of tumours. Bioinformatics analysis and a wide range of experiments were conducted to explore the expression status, specific function and molecular mechanism of long non-coding RNA ABHD11 antisense RNA 1 (ABHD11-AS1). ABHD11-AS1 knockdown repressed cell proliferation but enhanced cell apoptosis in function. We proved that miR-361-3p directly combines with the 3'wUTR of PDPK2 and ABHD11-AS1 cooperated with miR-361-3p to modulate PDPK2 mRNA and protein levels. Rescue assays confirmed that the miR-361-3p silence reversed the suppressive effect of ABHD11-AS1 deficiency. In summary, ABHD11-AS1 boosts GC development by regulating miR-361-3p/PDPK1 signalling.

References

Nov 7, 2012·Journal of Surgical Oncology·Douglas E Guggenheim, Manish A Shah
May 4, 2013·Gastroenterology Clinics of North America·Pelayo Correa
Mar 13, 2014·Cancer Epidemiology, Biomarkers & Prevention : a Publication of the American Association for Cancer Research, Cosponsored by the American Society of Preventive Oncology·Parisa KarimiFarin Kamangar
Oct 17, 2014·World Journal of Gastroenterology : WJG·Victor PasechnikovMarcis Leja
Jan 30, 2015·Singapore Medical Journal·Tiing Leong Ang, Kwong Ming Fock
Nov 30, 2016·Lancet·Liang ZongJiafu Ji
Jan 29, 2017·Gastric Cancer : Official Journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association·Sunpyo LeeJin-Ho Kim
Jul 4, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Zheyu SongXuedong Fang
Aug 18, 2017·Advances in Experimental Medicine and Biology·Julien JarrouxMarina Pinskaya
Aug 18, 2017·Advances in Experimental Medicine and Biology·Sonali JatharVidisha Tripathi
Aug 30, 2017·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Jin YanGuoxin Zhang
Sep 24, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Guijun ZhangRonggui Liu
Feb 23, 2020·Cancer Cell International·Fada XiaXinying Li

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