Long non-coding RNA AC023115.3 suppresses chemoresistance of glioblastoma by reducing autophagy

Biochimica Et Biophysica Acta. Molecular Cell Research
Binbin MaBo Zhang

Abstract

Malignant glioma is an aggressive brain cancer that responds poorly to chemotherapy. However, the molecular mechanism underlying the development of chemoresistance in glioma is not well-understood. In this study, we show that long non-coding RNA AC023115.3 is induced by cisplatin in human glioblastoma cells and that elevated AC023115.3 promotes cisplatin-induced apoptosis by inhibiting autophagy. Further mechanistic studies revealed that AC023115.3 acts as a competing endogenous RNA for miR-26a and attenuates the inhibitory effect of miR-26a on GSK3β, a proline-directed serine-threonine kinase that promotes the degradation of Mcl1, leading to an increase in GSK3β and a decrease in autophagy. Additionally, we discovered that AC023115.3 improves chemosensitivity of glioma cells to cisplatin by regulating the miR-26a-GSK3β-Mcl1 pathway. Thus, these data indicate that the AC023115.3-miR-26a-GSK3β signalling axis plays an important role in reducing the chemoresistance of glioma.

Citations

Feb 2, 2018·Journal of Experimental & Clinical Cancer Research : CR·Zhikun LinZhongyu Wang
Oct 6, 2017·Cell Death & Disease·Lixian YangHongchuan Jin
Sep 30, 2018·Bioscience Reports·Qingqing YinShaoqing Ju
Jan 30, 2019·Frontiers in Genetics·Md Zahirul Islam KhanHelen Ka Wai Law
Apr 9, 2020·Frontiers in Pharmacology·Jiabei ZhouLushan Yu
Jul 30, 2018·Journal of Experimental & Clinical Cancer Research : CR·Dongmei ZhangChuanchun Han
Jan 20, 2019·Journal of Experimental & Clinical Cancer Research : CR·Binbin MaBo Zhang
Mar 9, 2020·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Wenxiao JiangXueqiong Zhu
Jun 29, 2021·Frontiers in Oncology·Soudeh Ghafouri-FardGuive Sharifi
Jul 11, 2018·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Chang-Hong MaWen-Yue Ji

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