Long non-coding RNA and Polycomb: an intricate partnership in cancer biology.

Frontiers in Bioscience (Landmark Edition)
Cyrinne Achour, Francesca Aguilo

Abstract

High-throughput analyses have revealed that the vast majority of the transcriptome does not code for proteins. These non-translated transcripts, when larger than 200 nucleotides, are termed long non-coding RNAs (lncRNAs), and play fundamental roles in diverse cellular processes. LncRNAs are subject to dynamic chemical modification, adding another layer of complexity to our understanding of the potential roles that lncRNAs play in health and disease. Many lncRNAs regulate transcriptional programs by influencing the epigenetic state through direct interactions with chromatin-modifying proteins. Among these proteins, Polycomb repressive complexes 1 and 2 (PRC1 and PRC2) have been shown to be recruited by lncRNAs to silence target genes. Aberrant expression, deficiency or mutation of both lncRNA and Polycomb have been associated with numerous human diseases, including cancer. In this review, we have highlighted recent findings regarding the concerted mechanism of action of Polycomb group proteins (PcG), acting together with some classically defined lncRNAs including X-inactive specific transcript (XIST), antisense non-coding RNA in the INK4 locus (ANRIL), metastasis associated lung adenocarcinoma transcript 1 (MALAT1), and HOX tran...Continue Reading

Citations

Mar 7, 2021·Non-coding RNA·Shaymaa SadeqAndreas Werner
Oct 12, 2018·Journal of Cellular Biochemistry·Xiang LiuMeiyun Zheng
Feb 5, 2019·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·Joyce Bj van MeursJose A Riancho
May 31, 2019·International Journal of Molecular Sciences·Pavan Kumar Puvvula
Apr 20, 2021·Nucleic Acids Research·Charbel AlfeghalySylvain Maenner
Jun 24, 2020·Cancer Metastasis Reviews·Joy JonkersSaraswati Sukumar
Oct 18, 2020·Cell·Alexander F Palazzo, Eugene V Koonin
May 25, 2021·Journal of Cardiovascular Pharmacology·Jia-Li YuanQun-Shan Wang
Sep 10, 2021·Cell Proliferation·Hesuyuan HuangJianhao Lin

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