Long non-coding RNA CASC15 promotes melanoma progression by epigenetically regulating PDCD4

Cell & Bioscience
Yakun YinGuangwen Yin

Abstract

Long non-coding RNAs (LncRNAs) have been identified as critical regulators in a variety of cancer types. Cancer susceptibility candidate 15 (CASC15), a lncRNA located at chromosome 6p22.3, has been discovered to participate in melanoma progression and phenotype switching. Nevertheless, the roles and molecular mechanisms of CASC15 in melanoma are far from being understood. We found that CASC15 expression was up-regulated in melanoma tissues and associated with advanced pathological stages. Function experiments displayed that CASC15 knockdown hindered proliferation, facilitated apoptosis and suppressed invasion, while CASC15 overexpression facilitated proliferation and invasion in melanoma cells. Further mechanistic analysis showed that CASC15 epigenetically silenced the expression of programmed cell death 4 (PDCD4) by recruiting EZH2 and increasing H3K27me3 level at the promoter region of PDCD4. Additionally, PDCD4 overexpression inhibited proliferation, enhanced apoptosis and decreased invasion of melanoma cells. Moreover, CASC15-knockdown-induced anti-cancer effects were abated by PDCD4 down-regulation. Furthermore, depletion of CASC15 blocked tumor growth of melanoma by up-regulating PDCD4 in vivo. CASC15 acts as an oncogene ...Continue Reading

References

Mar 18, 2006·PLoS Computational Biology·Gustavo GlusmanArian F A Smit
Feb 23, 2007·Nature·Vanessa Gray-SchopferRichard Marais
Apr 10, 2009·Biology of the Cell·Brigitte Lankat-Buttgereit, Rüdiger Göke
Jul 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ahmad M KhalilJohn L Rinn
Sep 25, 2012·International Journal of Cancer. Journal International Du Cancer·Leonidas BenetatosEleftheria Hatzimichael
Jan 15, 2015·Epigenetics : Official Journal of the DNA Methylation Society·Debina SarkarMarjan E Askarian-Amiri
May 29, 2015·The Journal of Investigative Dermatology·Laurent LessardDave S B Hoon
Jun 24, 2015·Cancer Research·Mike R RussellKristina A Cole
Jan 9, 2016·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jan 6, 2017·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Jan 24, 2017·Cancer Letters·Ying TangTao Liu
Jun 1, 2017·International Journal of Molecular Sciences·Ke-Sin YanRuey-Hwang Chou
Jul 21, 2017·Molecular Cancer·Thilini R FernandoDinesh S Rao
Oct 14, 2017·Cancer Genetics·Weiliang SunJunming Guo
Nov 23, 2017·American Journal of Clinical Dermatology·Elisa A RozemanChristian U Blank
Dec 3, 2017·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nana NiJianfang Sun
Jan 2, 2018·Biochemical and Biophysical Research Communications·Jiang HuangYang Zhou
Jan 11, 2018·Steroids·Cristel V CamachoShrikanth S Gadad
Mar 28, 2018·Cell Proliferation·Xin YuWilliam Kk Wu

❮ Previous
Next ❯

Citations

May 6, 2019·Current Treatment Options in Oncology·Ion G Motofei
Apr 25, 2020·Journal of Cellular and Molecular Medicine·Hongjin ChenXiaohua Zhang
Apr 25, 2020·Molecular Genetics & Genomic Medicine·Ziying GaoTianbo Jin
Feb 6, 2020·Journal of Leukocyte Biology·Giuseppe ErcolanoCamilla Jandus
Dec 15, 2020·Cancer Gene Therapy·Xiang-Jun ChenXiao-Chun Zhao
Jan 13, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Xinyu GuHaihong Zhu
Jan 29, 2021·International Journal of Molecular Sciences·Vincenzo De FalcoTeresa Troiani
Feb 23, 2021·Bioinformatics and Biology Insights·Mozhdeh Shahmoradi, Zahra Rezvani
Oct 24, 2020·Experimental and Molecular Pathology·Amin SafaSoudeh Ghafouri-Fard

❮ Previous
Next ❯

Methods Mentioned

BETA
protein assay
Assay
immunoprecipitation
RIP
pull down
Pull
pull-down
flow cytometry
transfection
interaction prediction

Software Mentioned

GEPIA
SPSS

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.