Long non-coding RNA CRNDE and toll-like receptor 3 correlate with disease severity, inflammation, and mortality in sepsis.

Journal of Clinical Laboratory Analysis
Junhui YangLi Yu

Abstract

This study aimed to assess the interaction between long non-coding RNA colorectal neoplasia differentially expressed (lncRNA CRNDE) and toll-like receptor 3 (TLR3), and assess their correlations with disease severity, inflammation, and 28-days mortality in sepsis patients. We consecutively enrolled 146 sepsis patients and 146 healthy controls (HCs), and collected their peripheral blood mononuclear cells to detect lncRNA CRNDE and TLR3 expressions using reverse transcription quantitative polymerase chain reaction. LncRNA CRNDE and TLR3 in sepsis patients were classified into four clusters according to quantile expressions (Quantile 1 (0%-24%), Quantile 2 (25%-50%), Quantile 3 (50%-74%), and Quantile 4 (75%-100%)) for correlation analysis. LncRNA CRNDE was upregulated in sepsis patients compared with HCs, and it showed good value in differentiating sepsis patients form HCs by receiver operating characteristic curve analysis. In sepsis patients, lncRNA CRNDE positively correlated with acute pathologic and chronic health evaluation II (APACHE II) score and sequential organ failure assessment (SOFA) score, as well as serum creatinine (Scr). As for inflammation, lncRNA CRNDE positively correlated with C-reactive protein (CRP), tumor ...Continue Reading

References

Oct 8, 2008·The Journal of Experimental Medicine·Karen A CavassaniSteven L Kunkel
Aug 30, 2013·The New England Journal of Medicine·Derek C Angus, Tom van der Poll
Oct 25, 2013·The Journal of Immunology : Official Journal of the American Association of Immunologists·Lin ZouWei Chao
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Jun 21, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Weiying LiHui Wang
Jul 28, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Wen YeHong-Bing Shu
Oct 27, 2018·BioMed Research International·Fatemeh FattahiPeter A Ward
Jul 13, 2019·Cancer Management and Research·Tian-Yu HeGuang Li
Jan 29, 2020·Cleveland Clinic Journal of Medicine·Siddharth DugarAbhijit Duggal
Feb 23, 2020·Journal of Clinical Laboratory Analysis·Danna ZhaoYong Li

❮ Previous
Next ❯

Citations

May 28, 2021·Frontiers in Cardiovascular Medicine·Jiawen LiYifei Li
Jun 5, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Soudeh Ghafouri-FardMajid Mokhtari
Aug 14, 2021·Experimental Cell Research·Furong LuYiming Shao
Oct 7, 2021·Journal of Clinical Laboratory Analysis·Ting WangShao Zhou

❮ Previous
Next ❯

Methods Mentioned

BETA
density gradient centrifugation

Software Mentioned

GraphPad Prism
GraphPad
SPSS
Quantile

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.