Long non-coding RNA cytoskeleton regulator RNA (CYTOR) modulates pathological cardiac hypertrophy through miR-155-mediated IKKi signaling

Biochimica Et Biophysica Acta. Molecular Basis of Disease
Yuan YuanDi-Fei Shen

Abstract

Pathological cardiac hypertrophy, which may lead to heart failure and sudden death, can be affected by multiple factors. In our previous study, we revealed that IKKi deficiency induced cardiac hypertrophy through the activation of the AKT and NF-kB signaling pathway in response to aortic banding (AB). Non-coding RNAs, mainly long non-coding RNAs (lncRNAs) and microRNAs (miRNAs), play a crucial role in normal developmental and pathological processes. In the present study, microarray analysis results from GEO database were analyzed, and upregulated lncRNAs in cardiac hypertrophy were identified. Of them, lncRNA cytoskeleton regulator RNA (CYTOR) obtained a fold-change of 6.16 and was positively correlated with IKBKE according to the data from The GTEx project. CYTOR knockdown significantly enhanced the inducible effect of AB operation on mice myocardial hypertrophy and Angiotensin II on cardiomyocyte hypertrophy. Moreover, miR-155 was significantly related to hypertrophic cardiomyopathy (HCM, |hsa05410) and predicted to target both CYTOR and IKBKE. Luciferase reporter and RIP assays revealed that CYTOR served as a ceRNA for miR-155 to counteract miR-155-mediated repression of IKBKE. Moreover, CYTOR knockdown reduced IKKi protein ...Continue Reading

Citations

Oct 31, 2019·Heart Failure Reviews·Jinghui Sun, Chenglong Wang
May 16, 2020·Journal of Cellular and Molecular Medicine·Ling ZhangYu-Tao Xiang
Nov 7, 2019·Bioscience Reports·Cheng ChenBimei Jiang
Jan 3, 2020·International Journal of Molecular Medicine·Yungyong LiuHaozhe Piao
Oct 23, 2019·Biochimica Et Biophysica Acta. Reviews on Cancer·Subash C GuptaKishore B Challagundla
Jan 21, 2021·Frontiers in Cell and Developmental Biology·Dayin LyuQiulun Lu
May 6, 2021·International Journal of Molecular Sciences·Michaela AdamcovaFedor Simko
Jul 11, 2021·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Nahid AlimoradiReihaneh Fatehi

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