Long non-coding RNA FEZF1-AS1 facilitates cell proliferation and migration in colorectal carcinoma

Oncotarget
Na ChenJun Zhou

Abstract

Long non-coding RNAs (lncRNA) have been shown to play important roles in the development and progression of cancer. Here, we discovered a novel long noncoding RNA (lncRNA) FEZF1 antisense RNA1 (FEZF1-AS1) is markedly upregulated in human primary colorectal carcinoma (CRC) and associated with CRC metastasis and poor prognosis. Moreover, the downregulation of FEZF1-AS1 expression significantly inhibited the CRC cells proliferation, migration and invasiveness, suppressed S-phase entry in vitro, and repressed tumor growth and metastasis in vivo. In contrast, overexpression of FEZF1-AS1 could promote the aggressive behaviors of CRC cells. We further discovered that the downregulation of FEZF1-AS1 reduced its sense-cognate gene FEZF1 mRNA and protein expression in CRC cells. There was a positive correlation between FEZF1-AS1 and FEZF1 expression in CRC. Moreover, FEZF1 knockdown also significantly suppressed CRC cell proliferation, migration, and invasion. Our findings indicate that the dysregulation of FEZF1-AS1 participates in colorectal tumorigenesis and progression, which might be achieved, at least in part, through FEZF1 induction.

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Citations

May 6, 2016·Frontiers in Genetics·Ester SausCarles Pericay
Jun 24, 2017·Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine·Heng DengJun Zhang
Sep 12, 2019·Experimental Biology and Medicine·Jianxiong ChenJun Zhou
Apr 19, 2017·Oncotarget·He LiHong-Hao Zhou
Nov 27, 2016·Oncotarget·Yanfei YangShengtao Zhou
Apr 5, 2020·Clinical and Experimental Pharmacology & Physiology·Dong WangShengzhi Xie
May 4, 2018·Oncotarget·Zhixia ZhouJianxun Wang
Jul 31, 2019·Cellular Oncology (Dordrecht)·Ling WeiMing Yang
Sep 29, 2019·World Journal of Gastroenterology : WJG·Orsolya GalambBéla Molnár
May 8, 2019·Applied Microbiology and Biotechnology·Chit TamTzi Bun Ng
Mar 27, 2020·Cancer Management and Research·Lun LuoMeiqin Cai
Mar 7, 2020·Journal of Cellular and Molecular Medicine·Ziqian SunXiaojun Liu
Aug 10, 2017·Molecular Medicine Reports·Wenyi ZhuJun Zhou
Apr 4, 2019·BMC Genomics·Alberto Berral-GonzalezGuillermo Ayala
May 12, 2019·Bioscience Reports·Lian-Jiao Quan, Wen-Jun Wang
Jun 20, 2018·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Zehua BianZhaohui Huang
Jul 6, 2019·Clinica Chimica Acta; International Journal of Clinical Chemistry·Yuanshi ZhouXingming Jiang

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Methods Mentioned

BETA
transfection
flow cytometry
PCR
FACS
dissection

Software Mentioned

CELL Quest
SPSS

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