Long non-coding RNA FEZF1-AS1 induced progression of ovarian cancer via regulating miR-130a-5p/SOX4 axis.

Journal of Cellular and Molecular Medicine
Ziqian SunXiaojun Liu

Abstract

Emerging studies have revealed the critical role of long non-coding RNAs (lncRNAs) in epithelial ovarian cancer (EOC) development and progression. Till now, the roles and potential mechanisms regarding FEZF1 antisense RNA 1 (FEZF1-AS1) within ovarian cancer (OC) remain unclear. The objective of this study was to uncover the biological function and the underlying mechanism of LncRNA FEZF1-AS1 in OC progression. FEZF1-AS1 expression levels were studied in cell lines and tissues of human ovarian cancer. In vitro studies were performed to evaluate the impact of FEZF1-AS1 knock-down on the proliferation, invasion, migration and apoptosis of OC cells. Interactions of FEZF1-AS1 and its target genes were identified by luciferase reporter assays. Our data showed overexpression of FEZF1-AS1 in OC cell lines and tissues. Cell migration, proliferation, invasion, wound healing and colony formation were suppressed by silencing of FEZF1-AS1. In contrast, cell apoptosis was promoted by FEZF1-AS1 knock-down in vitro. Furthermore, online bioinformatics analysis and tools suggested that FEZF1-AS1 directly bound to miR-130a-5p and suppressed its expression. Moreover, the inhibitory effects of miR-130a-5p on the OC cell growth were reversed by FEZF...Continue Reading

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Citations

Apr 25, 2020·Cancers·Martín Salamini-MontemurriMaría Esperanza Cerdán
May 18, 2021·Frontiers in Cell and Developmental Biology·Toshihiko TakeiwaSatoshi Inoue
Aug 21, 2020·Pharmacological Research : the Official Journal of the Italian Pharmacological Society·Milad AshrafizadehMasoud Najafi

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Methods Mentioned

BETA
transfection
PCR
immunoprecipitation
flow cytometry
transfecting

Software Mentioned

SPSS
TargetScan
Image J

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