Long non-coding RNA GAS5 inhibits cell proliferation, induces G0/G1 arrest and apoptosis, and functions as a prognostic marker in colorectal cancer

Oncology Letters
Yang YangShan Wang

Abstract

Colorectal cancer (CRC) is the third most common cancer worldwide and its treatment remains a challenge. Effective control of cell survival and proliferation is critical in the prevention of oncogenesis and successful treatment of cancer. Long non-coding RNAs (lncRNAs) have emerged as primary regulators of carcinogenesis. Growth arrest specific 5 (GAS5), a lncRNA, is known to be aberrantly expressed in several types of cancer, however, the role of GAS5 in CRC remains unclear. In the present study, GAS5 mRNA expression was measured in CRC and adjacent normal mucosa tissue samples from 53 patients using reverse transcription-quantitative polymerase chain reaction analysis, in addition to seven CRC cell lines. GAS5 mRNA expression was observed to be markedly downregulated in human CRC tissues and cell lines. Decreased GAS5 expression was associated with an increase in tumor diameter [odds ratio (OR), 0.176 (95% CI, 0.053-0.586); P=0.003] and later tumor-node-metastasis stage [OR, 0.261 (95% CI, 0.083-0.819); P=0.019]. Patients with decreased GAS5 expression exhibited decreased overall survival rates compared with patients with increased GAS5 expression (P=0.015). The Cox proportional hazards model demonstrated that downregulated G...Continue Reading

References

Aug 26, 1998·Mammalian Genome : Official Journal of the International Mammalian Genome Society·A J MullerA J Levine
Feb 16, 2002·Methods : a Companion to Methods in Enzymology·K J Livak, T D Schmittgen
Mar 21, 2008·Journal of Cell Science·Mirna Mourtada-MaarabouniGwyn T Williams
Aug 23, 2008·Cell Cycle·Dmitri LodyginHeiko Hermeking
Feb 4, 2009·Nature Reviews. Genetics·Tim R MercerJohn S Mattick
Jul 3, 2009·Proceedings of the National Academy of Sciences of the United States of America·Ahmad M KhalilJohn L Rinn
Jul 3, 2009·Genes & Development·Jeremy E WiluszDavid L Spector
Feb 25, 2010·Annals of Surgical Oncology·Stephen B Edge, Carolyn C Compton
Sep 20, 2011·Molecular Cell·Kevin C Wang, Howard Y Chang
Oct 13, 2011·PloS One·Ewan A GibbWan L Lam
Nov 19, 2011·Cancer Discovery·John R Prensner, Arul M Chinnaiyan
Jan 20, 2012·Cancer Research·Takeshi NiinumaYasuhisa Shinomura
Mar 7, 2012·Journal of Molecular Endocrinology·Yunli ZhouAnne Klibanski
Jun 6, 2012·RNA Biology·Tony Gutschner, Sven Diederichs
May 17, 2013·Biochimica Et Biophysica Acta·M R PickardG T Williams
Mar 8, 2014·Circulation Research·Katharina M MichalikStefanie Dimmeler
Mar 19, 2014·CA: a Cancer Journal for Clinicians·Rebecca SiegelAhmedin Jemal
Jun 3, 2014·Molecular Cancer·Arun RenganathanEmanuela Felley-Bosco
Jun 14, 2014·Brain Tumor Research and Treatment·Ju Young ParkJong Heon Kim
Apr 2, 2016·Clinical Colorectal Cancer·Vassilis PapadopoulosKonstantinos Kamposioras

❮ Previous
Next ❯

Citations

May 9, 2018·Journal of Cellular Biochemistry·Xiaoli HuXia Qin
Jan 5, 2019·Bioscience Reports·Shounan LuSheng Tai
Nov 7, 2019·Cancer Medicine·Huan YangShiming Yang
Sep 13, 2018·International Journal of Molecular Sciences·Jana-Aletta ThielePavel Pitule
Oct 12, 2019·Experimental and Therapeutic Medicine·Yuxia DuanLing Zhang
Oct 22, 2019·Frontiers in Oncology·Mercedes BermúdezRosalío Ramos-Payán
Feb 6, 2020·Frontiers in Oncology·Qinglian HeWei Zhu
Dec 17, 2017·Cancer Metastasis Reviews·Tony GutschnerMartin Pichler
Oct 9, 2019·Cancer Biomarkers : Section a of Disease Markers·Zhenhai JingQing Hong
Sep 19, 2019·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Yongchao LiuSheng Wang
Feb 11, 2021·Personalized Medicine·Alicja ZalewskiScott A Waldman
Mar 16, 2021·Frontiers in Oncology·Zhiming LiaoChunlin Ou
Apr 12, 2019·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·Soudeh Ghaforui-Fard, Mohammad Taheri
Sep 16, 2021·The Journal of International Medical Research·Shushan ZhaoLanhua Tang

❮ Previous
Next ❯

Related Concepts

Related Feeds

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.