Long non-coding RNA H19 in atherosclerosis: what role?

Molecular Medicine
Xian ShiGuo-Jun Zhao

Abstract

Atherosclerosis (AS) is widely accepted to be a multistep pathophysiological process associated with several other processes such as angiogenesis and inflammatory response. Long non-coding RNAs (lncRNAs) are non-protein coding RNAs (more than 200 nucleotides in length) and can regulate gene expression at the transcriptional and post-transcriptional levels. Recent studies suggest that lncRNA-H19 plays important roles in the regulation of angiogenesis, adipocyte differentiation, lipid metabolism, inflammatory response, cellular proliferation and apoptosis. In this review, we primarily discuss the roles of lncRNA-H19 in atherosclerosis-related pathophysiological processes and the potential mechanisms by which lncRNA-H19 regulates the development of atherosclerosis, to help provide a better understanding of the biological functions of lncRNA-H19 in atherosclerosis.

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Citations

Apr 24, 2020·Circulation Research·Nicolas Jaé, Stefanie Dimmeler
Jun 18, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Chengqi YanZhenbing Chen
Aug 3, 2021·Diabetes, Metabolic Syndrome and Obesity : Targets and Therapy·Shidong TanZhongqun Wang
Aug 24, 2021·Frontiers in Pharmacology·Shi-Feng HuangWen-Chu Ye

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