Long non-coding RNA Irm enhances myogenic differentiation by interacting with MEF2D

Cell Death & Disease
Yutong SuiGuangyu Li

Abstract

Recent studies suggest important roles for long non-coding RNAs as essential regulators of myogenic differentiation. Here, we report that lncRNA Irm is upregulated during myogenesis. Functional analyses show that the overexpression of Irm enhances myogenic differentiation, whereas the inhibition of Irm has completely opposite effects in vitro. Notably, the inhibition of Irm blocks damage-induced muscle regeneration in vivo. Mechanistically, Irm regulates the expression of myogenic genes by directly binding to MEF2D, which in turn promotes the assembly of MyoD/MEF2D on the regulatory elements of target genes. Collectively, we have identified a novel lncRNA that interacts with MEF2D to regulate myogenesis.

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Citations

Aug 1, 2019·Acta Physiologica·Rui ChenYanling She
Nov 5, 2019·Frontiers in Cell and Developmental Biology·Sweta SwetaRaghu Bhushan
Mar 3, 2020·Frontiers in Cell and Developmental Biology·Julie MartoneMonica Ballarino
Dec 10, 2020·Proceedings of the National Academy of Sciences of the United States of America·Anqi DongTom H Cheung
Dec 17, 2020·Frontiers in Cell and Developmental Biology·Jingxuan LiChangchun Li
Dec 7, 2020·Molecular Therapy : the Journal of the American Society of Gene Therapy·Jin LiJunjie Xiao
Jan 21, 2021·Clinical Epigenetics·Anna RugowskaPatryk Konieczny
Aug 16, 2019·Emerging Topics in Life Sciences·Simona CantarellaBarbara Montanini
Nov 2, 2021·Frontiers in Cell and Developmental Biology·Shu-Juan XieZhen-Dong Xiao

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Methods Mentioned

BETA
pull-down
immunoprecipitation
electrophoresis
ChIP
ChIRP
in vitro transcription
RIP
Assay

Software Mentioned

GraphPad Prism
ImageJ

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